Matrix-induced nuclear remodeling and mechano-therapeutics
Summary: The extracellular matrix (ECM) provides structural support and mechanical cues that profoundly influence cellular behavior via nuclear mechanotransduction. This review discusses how ECM biophysical properties, including stiffness, topology, and spatial confinement, regulate nuclear mechanic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725009477 |
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| author | Jung-Hwan Lee Yeo Gyun Yun Hae-Won Kim |
| author_facet | Jung-Hwan Lee Yeo Gyun Yun Hae-Won Kim |
| author_sort | Jung-Hwan Lee |
| collection | DOAJ |
| description | Summary: The extracellular matrix (ECM) provides structural support and mechanical cues that profoundly influence cellular behavior via nuclear mechanotransduction. This review discusses how ECM biophysical properties, including stiffness, topology, and spatial confinement, regulate nuclear mechanics and chromatin organization to determine cell fate across diverse pathophysiological contexts. We describe how mechanical signals propagate from the plasma membrane through cytoskeletal networks to modulate nuclear envelope tension, chromatin accessibility, and epigenetic landscapes. These matrix-driven nuclear changes orchestrate cellular responses in cancer progression, inflammation, fibrosis, stem cell differentiation, and age-related tissue dysfunction. Building on this mechanistic insight, we highlight emerging therapeutic strategies targeting the matrix-nucleus axis, such as tuning matrix properties to modulate chromatin accessibility, mechano-priming cells to enhance therapeutic outcomes, and targeting mechanosensitive molecules in the cytoskeletal-nuclear interface. Collectively, these approaches represent a promising paradigm leveraging mechanically induced epigenetic regulation and nuclear mechanobiology for disease treatment and tissue regeneration. |
| format | Article |
| id | doaj-art-c5fb6dc828f04c8297da7055cb78ca53 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-c5fb6dc828f04c8297da7055cb78ca532025-08-24T05:12:07ZengElsevierCell Reports2211-12472025-09-0144911617610.1016/j.celrep.2025.116176Matrix-induced nuclear remodeling and mechano-therapeuticsJung-Hwan Lee0Yeo Gyun Yun1Hae-Won Kim2Intitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Department of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea; Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of KoreaIntitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of KoreaIntitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Department of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea; Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea; Corresponding authorSummary: The extracellular matrix (ECM) provides structural support and mechanical cues that profoundly influence cellular behavior via nuclear mechanotransduction. This review discusses how ECM biophysical properties, including stiffness, topology, and spatial confinement, regulate nuclear mechanics and chromatin organization to determine cell fate across diverse pathophysiological contexts. We describe how mechanical signals propagate from the plasma membrane through cytoskeletal networks to modulate nuclear envelope tension, chromatin accessibility, and epigenetic landscapes. These matrix-driven nuclear changes orchestrate cellular responses in cancer progression, inflammation, fibrosis, stem cell differentiation, and age-related tissue dysfunction. Building on this mechanistic insight, we highlight emerging therapeutic strategies targeting the matrix-nucleus axis, such as tuning matrix properties to modulate chromatin accessibility, mechano-priming cells to enhance therapeutic outcomes, and targeting mechanosensitive molecules in the cytoskeletal-nuclear interface. Collectively, these approaches represent a promising paradigm leveraging mechanically induced epigenetic regulation and nuclear mechanobiology for disease treatment and tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2211124725009477CP: Cell biology |
| spellingShingle | Jung-Hwan Lee Yeo Gyun Yun Hae-Won Kim Matrix-induced nuclear remodeling and mechano-therapeutics Cell Reports CP: Cell biology |
| title | Matrix-induced nuclear remodeling and mechano-therapeutics |
| title_full | Matrix-induced nuclear remodeling and mechano-therapeutics |
| title_fullStr | Matrix-induced nuclear remodeling and mechano-therapeutics |
| title_full_unstemmed | Matrix-induced nuclear remodeling and mechano-therapeutics |
| title_short | Matrix-induced nuclear remodeling and mechano-therapeutics |
| title_sort | matrix induced nuclear remodeling and mechano therapeutics |
| topic | CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725009477 |
| work_keys_str_mv | AT junghwanlee matrixinducednuclearremodelingandmechanotherapeutics AT yeogyunyun matrixinducednuclearremodelingandmechanotherapeutics AT haewonkim matrixinducednuclearremodelingandmechanotherapeutics |