Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study
Plaque psoriasis is the most common type of psoriasis that manifests as red scaly patches with white scales affecting body areas including scalp, elbows, knees, trunk, and buttocks. Although many treatment options are available including novel biologics, no cure is available. Mesenchymal stem cells...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/4617520 |
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| author | Sebo Gene Wang Nicholas C. Hsu Sebo Michelle Wang Fu Nan Wang |
| author_facet | Sebo Gene Wang Nicholas C. Hsu Sebo Michelle Wang Fu Nan Wang |
| author_sort | Sebo Gene Wang |
| collection | DOAJ |
| description | Plaque psoriasis is the most common type of psoriasis that manifests as red scaly patches with white scales affecting body areas including scalp, elbows, knees, trunk, and buttocks. Although many treatment options are available including novel biologics, no cure is available. Mesenchymal stem cells (MSCs) have been safely used to treat a variety of human diseases. Allogeneic MSCs possess unique characteristics including hypoimmunogenicity, immunomodulatory, and anti-inflammatory properties, and they are currently being explored for potential therapeutic use for many systemic inflammatory diseases. The human gingival tissue is an easily accessible and obtainable source for the isolation of MSCs. MSCs from adult human gingiva are of fetal-like phenotype, multipotent, and easy to isolate and expand in vitro. Herein, we report a case of a 19-year-old man with a 5-year history of severe plaque psoriasis refractory to multiple topical and systemic therapies who was treated with allogeneic human gingival MSCs. Complete regression was achieved after 5 infusions with no adverse reaction occurred. The patient has been followed for three years and has remained disease free. |
| format | Article |
| id | doaj-art-c5fa911df7a4464da4d3b0d9d3f7167e |
| institution | OA Journals |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-c5fa911df7a4464da4d3b0d9d3f7167e2025-08-20T02:18:38ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/46175204617520Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case StudySebo Gene Wang0Nicholas C. Hsu1Sebo Michelle Wang2Fu Nan Wang3Top IVF USA, Hacienda Heights, CA, USATop IVF USA, Hacienda Heights, CA, USALoma Linda University School of Medicine, Loma Linda, CA, USATop IVF USA, Hacienda Heights, CA, USAPlaque psoriasis is the most common type of psoriasis that manifests as red scaly patches with white scales affecting body areas including scalp, elbows, knees, trunk, and buttocks. Although many treatment options are available including novel biologics, no cure is available. Mesenchymal stem cells (MSCs) have been safely used to treat a variety of human diseases. Allogeneic MSCs possess unique characteristics including hypoimmunogenicity, immunomodulatory, and anti-inflammatory properties, and they are currently being explored for potential therapeutic use for many systemic inflammatory diseases. The human gingival tissue is an easily accessible and obtainable source for the isolation of MSCs. MSCs from adult human gingiva are of fetal-like phenotype, multipotent, and easy to isolate and expand in vitro. Herein, we report a case of a 19-year-old man with a 5-year history of severe plaque psoriasis refractory to multiple topical and systemic therapies who was treated with allogeneic human gingival MSCs. Complete regression was achieved after 5 infusions with no adverse reaction occurred. The patient has been followed for three years and has remained disease free.http://dx.doi.org/10.1155/2020/4617520 |
| spellingShingle | Sebo Gene Wang Nicholas C. Hsu Sebo Michelle Wang Fu Nan Wang Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study Case Reports in Dermatological Medicine |
| title | Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study |
| title_full | Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study |
| title_fullStr | Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study |
| title_full_unstemmed | Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study |
| title_short | Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study |
| title_sort | successful treatment of plaque psoriasis with allogeneic gingival mesenchymal stem cells a case study |
| url | http://dx.doi.org/10.1155/2020/4617520 |
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