EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604
The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Poltava State Medical University
2018-12-01
|
| Series: | Проблеми екології та медицини |
| Subjects: | |
| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/140 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849471568595386368 |
|---|---|
| author | T. M. Popova |
| author_facet | T. M. Popova |
| author_sort | T. M. Popova |
| collection | DOAJ |
| description | The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period. |
| format | Article |
| id | doaj-art-c5f2b2a7e070471995e1c1d30dc4f41c |
| institution | Kabale University |
| issn | 2073-4662 2519-2302 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Poltava State Medical University |
| record_format | Article |
| series | Проблеми екології та медицини |
| spelling | doaj-art-c5f2b2a7e070471995e1c1d30dc4f41c2025-08-20T03:24:47ZengPoltava State Medical UniversityПроблеми екології та медицини2073-46622519-23022018-12-01225-6192110.31718/mep.2018.22.5-6.04140EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604T. M. Popova0Kharkiv national medical university, Kharkiv, UkraineThe article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period.https://ecomed-journal.org/index.php/journal/article/view/140laprol-604, surfactant, reproductive toxicity, developmental toxicity, gestation day, postnatal day |
| spellingShingle | T. M. Popova EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 Проблеми екології та медицини laprol-604, surfactant, reproductive toxicity, developmental toxicity, gestation day, postnatal day |
| title | EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 |
| title_full | EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 |
| title_fullStr | EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 |
| title_full_unstemmed | EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 |
| title_short | EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604 |
| title_sort | evaluation of growth and development of rat pups prenatally exposed to laprol 604 |
| topic | laprol-604, surfactant, reproductive toxicity, developmental toxicity, gestation day, postnatal day |
| url | https://ecomed-journal.org/index.php/journal/article/view/140 |
| work_keys_str_mv | AT tmpopova evaluationofgrowthanddevelopmentofratpupsprenatallyexposedtolaprol604 |