Exosomal let-7b-5p derived from Aspergillus fumigatus-treated human corneal epithelial cells promotes M1 macrophage activation via targeting SOCS-1

Exosomal let-7b-5p derived from Aspergillus fumigatus-treated human corneal epithelial cells promotes M1 macrophage activation via targeting SOCS-1

PurposeThis study aimed to explore the impact of exosomal miRNAs derived from Aspergillus fumigatus (A. fumigatus)-treated human corneal epithelial cells (HCECs) on M1 macrophage activation. We further clarified the mechanisms contributing to M1 macrophage activation in fungal keratitis.MethodsExoso...

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Bibliographic Details
Main Authors: Xiaoming Yu, Xinyi Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
fungal keratitis
exosomes
let-7b-5p
SOCS-1
M1 macrophage activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1548802/full
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