Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital
<b>Background</b>: The diagnosis of hemodynamically significant patent ductus arteriosus (hsPDA) occurs in 55% of very low birth weight (VLBW) preterm infants. There is no agreement on the best approach to ensure a quick hsPDA closure. Drug treatment of hsPDA fails in approximately 20% o...
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MDPI AG
2025-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/5/577 |
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| author | Samuele Caruggi Andrea Calandrino Gaia Cipresso Marcella Battaglini Paolo Massirio Francesco Vinci Irene Bonato Chiara Andreato Federica Mela Lorenzo Curcio Alessandro Parodi Luca Antonio Ramenghi |
| author_facet | Samuele Caruggi Andrea Calandrino Gaia Cipresso Marcella Battaglini Paolo Massirio Francesco Vinci Irene Bonato Chiara Andreato Federica Mela Lorenzo Curcio Alessandro Parodi Luca Antonio Ramenghi |
| author_sort | Samuele Caruggi |
| collection | DOAJ |
| description | <b>Background</b>: The diagnosis of hemodynamically significant patent ductus arteriosus (hsPDA) occurs in 55% of very low birth weight (VLBW) preterm infants. There is no agreement on the best approach to ensure a quick hsPDA closure. Drug treatment of hsPDA fails in approximately 20% of cases with an increasing risk of prolonged ventilation, BPD, and NEC, as well as the need for surgical duct ligation. This study aims to highlight the efficacy of ibuprofen versus acetaminophen in the case of a second cycle of medical therapy after the failure of the first pharmacological approach for hsPDA closure. <b>Methods</b>: Every VLBW infant admitted to our NICU and treated for hsPDA was included in our retrospective research. Information about the clinical course, hsPDA diagnosis and treatment, and common complications associated with preterm birth was collected. A comparison was made between patients treated with acetaminophen or ibuprofen to assess effectiveness in hsPDA closing. <b>Results</b>: A total of 286 VLBW infants were included. First-course ibuprofen was effective in 87 of 115 infants (75.7%) treated, acetaminophen in 138 of 171 (80.7%). Second-course therapy with ibuprofen was effective in 62.5% of the patients, while acetaminophen was effective in 69.2%. No statistically significant difference was observed in the first-course and second-course success rates. <b>Conclusions</b>: This study confirms that acetaminophen is not inferior to ibuprofen in the closure of hsPDA in VLBW infants. Our data demonstrate that a second course of medical therapy after the failure of the first course could help close the majority of hsPDA cases without surgery. |
| format | Article |
| id | doaj-art-c5ed6720f745419097d7fd2dee396c90 |
| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-c5ed6720f745419097d7fd2dee396c902025-08-20T03:47:48ZengMDPI AGChildren2227-90672025-04-0112557710.3390/children12050577Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s HospitalSamuele Caruggi0Andrea Calandrino1Gaia Cipresso2Marcella Battaglini3Paolo Massirio4Francesco Vinci5Irene Bonato6Chiara Andreato7Federica Mela8Lorenzo Curcio9Alessandro Parodi10Luca Antonio Ramenghi11Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, ItalyNeonatal Intensive Care Unit, Department of Maternal and Neonatal Health, IRCCS Giannina Gaslini Institute, 16147 Genoa, Italy<b>Background</b>: The diagnosis of hemodynamically significant patent ductus arteriosus (hsPDA) occurs in 55% of very low birth weight (VLBW) preterm infants. There is no agreement on the best approach to ensure a quick hsPDA closure. Drug treatment of hsPDA fails in approximately 20% of cases with an increasing risk of prolonged ventilation, BPD, and NEC, as well as the need for surgical duct ligation. This study aims to highlight the efficacy of ibuprofen versus acetaminophen in the case of a second cycle of medical therapy after the failure of the first pharmacological approach for hsPDA closure. <b>Methods</b>: Every VLBW infant admitted to our NICU and treated for hsPDA was included in our retrospective research. Information about the clinical course, hsPDA diagnosis and treatment, and common complications associated with preterm birth was collected. A comparison was made between patients treated with acetaminophen or ibuprofen to assess effectiveness in hsPDA closing. <b>Results</b>: A total of 286 VLBW infants were included. First-course ibuprofen was effective in 87 of 115 infants (75.7%) treated, acetaminophen in 138 of 171 (80.7%). Second-course therapy with ibuprofen was effective in 62.5% of the patients, while acetaminophen was effective in 69.2%. No statistically significant difference was observed in the first-course and second-course success rates. <b>Conclusions</b>: This study confirms that acetaminophen is not inferior to ibuprofen in the closure of hsPDA in VLBW infants. Our data demonstrate that a second course of medical therapy after the failure of the first course could help close the majority of hsPDA cases without surgery.https://www.mdpi.com/2227-9067/12/5/577hsPDAacetaminophenibuprofen |
| spellingShingle | Samuele Caruggi Andrea Calandrino Gaia Cipresso Marcella Battaglini Paolo Massirio Francesco Vinci Irene Bonato Chiara Andreato Federica Mela Lorenzo Curcio Alessandro Parodi Luca Antonio Ramenghi Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital Children hsPDA acetaminophen ibuprofen |
| title | Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital |
| title_full | Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital |
| title_fullStr | Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital |
| title_full_unstemmed | Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital |
| title_short | Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children’s Hospital |
| title_sort | second attempt for patent ductus arteriosus pda closure room for acetaminophen a retrospective single center experience at gaslini children s hospital |
| topic | hsPDA acetaminophen ibuprofen |
| url | https://www.mdpi.com/2227-9067/12/5/577 |
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