Treatment of Hemorrhagic Fever with Renal Syndrome: Pathophysiologic Rationale and Practical Application
Current treatment of hemorrhagic fever with renal syndrome (HFRS) is primarily based on expert opinion and data from small observational studies, the results of which are not always confirmed in clinical practice. Due to the lack of effective antiviral agents for the treatment of HFRS, the search fo...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2025-07-01
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| Series: | Архивъ внутренней медицины |
| Subjects: | |
| Online Access: | https://www.medarhive.ru/jour/article/view/2043 |
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| Summary: | Current treatment of hemorrhagic fever with renal syndrome (HFRS) is primarily based on expert opinion and data from small observational studies, the results of which are not always confirmed in clinical practice. Due to the lack of effective antiviral agents for the treatment of HFRS, the search for optimal supportive therapy continues. The clinical course of HFRS is characterized by the sequential development of phases of fever, hypotension, oliguria, polyuria and convalescence; each of these phases is characterized by certain pathophysiological mechanisms, knowledge of which is necessary for the correct management of patients with HFRS. This narrative review provides the pathophysilogic rationale and practical experience of using treatment methods for HFRS, such as anti-inflammatory therapy, correction of fluid, electrolyte, hemodynamic and hemocoagulation disorders, as well as, renal replacement therapy and symptomatic therapy. |
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| ISSN: | 2226-6704 2411-6564 |