Antiviral therapy of hepatitis C with 1 genotype after liver transplantation
Chronic HCV infection is the leading cause of liver transplantation in adults in developed countries. Unfortunately, the reinfection of the graft inevitably occurs in all patients with persistent replication of the virus. Against the background of the necessary immunosuppressive therapy, the progr...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2018-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/919 |
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| _version_ | 1849691188748091392 |
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| author | O. M. Tsiroulnikova D. V. Umrik |
| author_facet | O. M. Tsiroulnikova D. V. Umrik |
| author_sort | O. M. Tsiroulnikova |
| collection | DOAJ |
| description | Chronic HCV infection is the leading cause of liver transplantation in adults in developed countries. Unfortunately, the reinfection of the graft inevitably occurs in all patients with persistent replication of the virus. Against the background of the necessary immunosuppressive therapy, the progression of the disease accelerates, leading to rapid decompensation of the liver. Antiviral therapy significantly improves the results of transplantation, but the use of standard interferon-based regimens is associated with low efficacy (no more than 30% for the most common 1 genotype of the virus) and poor tolerance. The article describes new interferon- free oral regimens used to treat the recurrence of HCV infection of 1 genotype. |
| format | Article |
| id | doaj-art-c5e60e1c1c1944e39086bcd6953447ab |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-c5e60e1c1c1944e39086bcd6953447ab2025-08-20T03:21:06ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912018-09-0120310511510.15825/1995-1191-2018-3-105-115728Antiviral therapy of hepatitis C with 1 genotype after liver transplantationO. M. Tsiroulnikova0D. V. Umrik1V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationChronic HCV infection is the leading cause of liver transplantation in adults in developed countries. Unfortunately, the reinfection of the graft inevitably occurs in all patients with persistent replication of the virus. Against the background of the necessary immunosuppressive therapy, the progression of the disease accelerates, leading to rapid decompensation of the liver. Antiviral therapy significantly improves the results of transplantation, but the use of standard interferon-based regimens is associated with low efficacy (no more than 30% for the most common 1 genotype of the virus) and poor tolerance. The article describes new interferon- free oral regimens used to treat the recurrence of HCV infection of 1 genotype.https://journal.transpl.ru/vtio/article/view/919chronic hepatitis crelapseliver transplantationdirect antiviral actionresistant virologic response. |
| spellingShingle | O. M. Tsiroulnikova D. V. Umrik Antiviral therapy of hepatitis C with 1 genotype after liver transplantation Вестник трансплантологии и искусственных органов chronic hepatitis c relapse liver transplantation direct antiviral action resistant virologic response. |
| title | Antiviral therapy of hepatitis C with 1 genotype after liver transplantation |
| title_full | Antiviral therapy of hepatitis C with 1 genotype after liver transplantation |
| title_fullStr | Antiviral therapy of hepatitis C with 1 genotype after liver transplantation |
| title_full_unstemmed | Antiviral therapy of hepatitis C with 1 genotype after liver transplantation |
| title_short | Antiviral therapy of hepatitis C with 1 genotype after liver transplantation |
| title_sort | antiviral therapy of hepatitis c with 1 genotype after liver transplantation |
| topic | chronic hepatitis c relapse liver transplantation direct antiviral action resistant virologic response. |
| url | https://journal.transpl.ru/vtio/article/view/919 |
| work_keys_str_mv | AT omtsiroulnikova antiviraltherapyofhepatitiscwith1genotypeafterlivertransplantation AT dvumrik antiviraltherapyofhepatitiscwith1genotypeafterlivertransplantation |