Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN)
The aim of the present study was to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (ZEN). In total, 168 pigs were equally allocated in four experi...
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MDPI AG
2025-03-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/17/3/146 |
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| author | Jog Raj Panagiotis Tassis Klaus Männer Hunor Farkaš Zdenka Jakovčević Marko Vasiljević |
| author_facet | Jog Raj Panagiotis Tassis Klaus Männer Hunor Farkaš Zdenka Jakovčević Marko Vasiljević |
| author_sort | Jog Raj |
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| description | The aim of the present study was to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (ZEN). In total, 168 pigs were equally allocated in four experimental groups from day 25 to day 66 of age. The T1 group received feed without mycotoxins or MMDA. The pigs in group T2 received contaminated feed (CF) with 1.5 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the first two weeks and 1.2 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the rest of the trial period, without the addition of MMDA. Groups T3 and T4 received the CF with the addition of 1.5 g of MMDA/kg feed (T3), or 3 g of MMDA/kg feed (T4). Performance parameters, stress, and inflammatory biomarkers, as well as mycotoxin residues in liver, kidney, and muscle tissue were assessed. The results demonstrated improved average daily gain (ADG) and feed conversion ratio (FCR) along with reduced DON residues in kidney samples in groups T3 and T4 when compared with the T2 group. Although a typical dose–response relationship was not present in all parameter alterations, the results of the study proved the efficacy of the test product with improved growth performance and reduced mycotoxins absorption under the concurrent DON and ZEN exposure conditions and supported its use as a mitigating tool against mycotoxicosis under field conditions. |
| format | Article |
| id | doaj-art-c5e57cac185645ca9de0a6b0b43fb886 |
| institution | Kabale University |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Toxins |
| spelling | doaj-art-c5e57cac185645ca9de0a6b0b43fb8862025-08-20T03:44:01ZengMDPI AGToxins2072-66512025-03-0117314610.3390/toxins17030146Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN)Jog Raj0Panagiotis Tassis1Klaus Männer2Hunor Farkaš3Zdenka Jakovčević4Marko Vasiljević5Patent Co, DOO., Vlade Ćetkovića 1A, 24211 Mišićevo, SerbiaFarm Animals Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, 54627 Thessaloniki, GreeceInstitute of Animal Nutrition, Freie Universität Berlin, Königin-Luise-Str. 49, 14195 Berlin, GermanyPatent Co, DOO., Vlade Ćetkovića 1A, 24211 Mišićevo, SerbiaPatent Co, DOO., Vlade Ćetkovića 1A, 24211 Mišićevo, SerbiaPatent Co, DOO., Vlade Ćetkovića 1A, 24211 Mišićevo, SerbiaThe aim of the present study was to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (ZEN). In total, 168 pigs were equally allocated in four experimental groups from day 25 to day 66 of age. The T1 group received feed without mycotoxins or MMDA. The pigs in group T2 received contaminated feed (CF) with 1.5 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the first two weeks and 1.2 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the rest of the trial period, without the addition of MMDA. Groups T3 and T4 received the CF with the addition of 1.5 g of MMDA/kg feed (T3), or 3 g of MMDA/kg feed (T4). Performance parameters, stress, and inflammatory biomarkers, as well as mycotoxin residues in liver, kidney, and muscle tissue were assessed. The results demonstrated improved average daily gain (ADG) and feed conversion ratio (FCR) along with reduced DON residues in kidney samples in groups T3 and T4 when compared with the T2 group. Although a typical dose–response relationship was not present in all parameter alterations, the results of the study proved the efficacy of the test product with improved growth performance and reduced mycotoxins absorption under the concurrent DON and ZEN exposure conditions and supported its use as a mitigating tool against mycotoxicosis under field conditions.https://www.mdpi.com/2072-6651/17/3/146weaned pigsdeoxynivalenolzearalenonemycotoxinshealthinflammatory biomarkers |
| spellingShingle | Jog Raj Panagiotis Tassis Klaus Männer Hunor Farkaš Zdenka Jakovčević Marko Vasiljević Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) Toxins weaned pigs deoxynivalenol zearalenone mycotoxins health inflammatory biomarkers |
| title | Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) |
| title_full | Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) |
| title_fullStr | Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) |
| title_full_unstemmed | Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) |
| title_short | Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) |
| title_sort | effects of a multicomponent mycotoxin detoxifying agent on health and performance of weaned pigs under combined dietary exposure to deoxynivalenol don and zearalenone zen |
| topic | weaned pigs deoxynivalenol zearalenone mycotoxins health inflammatory biomarkers |
| url | https://www.mdpi.com/2072-6651/17/3/146 |
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