CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.

CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.

Chronic viral infections lead to persistent CD8 T cell activation and functional exhaustion. Expression of programmed cell death-1 (PD-1) has been associated to CD8 T cell dysfunction in HIV infection. Herein we report that another negative regulator of T cell activation, CD160, was also upregulated...

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Main Authors: Yoav Peretz, Zhong He, Yu Shi, Bader Yassine-Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali-Mouhim, Jean-Baptiste Loubert, Mohamed El-Far, Franck P Dupuy, Mohamed Rachid Boulassel, Cécile Tremblay, Jean-Pierre Routy, Nicole Bernard, Robert Balderas, Elias K Haddad, Rafick-Pierre Sékaly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002840&type=printable
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