Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies
This study examined the phytochemical profile and biomedical activities of <i>Nitraria retusa</i>, a halophytic and drought-resistant shrub. HPLC analysis showed gallic acid (1905.1 μg/g), catechin (1984.1 μg/g), and ellagic acid (2671.1 μg/g) as the primary constituents, while FT-IR ana...
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2024-12-01
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| author | Manal M. Khowdiary Zinab Alatawi Amirah Alhowiti Mohamed A. Amin Hussam Daghistani Faisal Miqad K. Albaqami Mohamed Ali Abdel-Rahman Ahmed Ghareeb Nehad A. Shaer Ahmed M. Shawky Amr Fouda |
| author_facet | Manal M. Khowdiary Zinab Alatawi Amirah Alhowiti Mohamed A. Amin Hussam Daghistani Faisal Miqad K. Albaqami Mohamed Ali Abdel-Rahman Ahmed Ghareeb Nehad A. Shaer Ahmed M. Shawky Amr Fouda |
| author_sort | Manal M. Khowdiary |
| collection | DOAJ |
| description | This study examined the phytochemical profile and biomedical activities of <i>Nitraria retusa</i>, a halophytic and drought-resistant shrub. HPLC analysis showed gallic acid (1905.1 μg/g), catechin (1984.1 μg/g), and ellagic acid (2671.1 μg/g) as the primary constituents, while FT-IR analysis revealed a complex organic profile with significant functional groups. The extract demonstrated strong antioxidant activity in DPPH assays, outperforming ascorbic acid (IC<sub>50</sub> = 18.7 ± 1.0 μg/mL) with an IC<sub>50</sub> of 16.4 ± 4.4 μg/mL. It demonstrated specific antiproliferative effects on cancer cell lines as it showed selective cytotoxicity against cancer cell lines; normal WI38 cells were largely unaffected, showing 50.0% viability at 125 μg/mL. The most sensitive cell line was Caco2, which showed 50.0% viability at 125 μg/mL. Anti-diabetic properties were exhibited by means of inhibition of α-amylase (IC<sub>50</sub> = 68.2 ± 4.2 μg/mL) and α-glucosidase (IC<sub>50</sub> = 22.8 ± 3.3 μg/mL). Additionally, antimicrobial activity was observed to be broad-spectrum, and it was most effective against <i>E. coli</i> (32.6 mm inhibition zone at 400 μg/mL) and <i>Penicillium glabrum</i> (35.3 mm at 400 μg/mL). These findings highlight the potential of <i>N. retusa</i> in developing plant-based therapeutic approaches. |
| format | Article |
| id | doaj-art-c5dfa93d452e4c28bcacbbfc783c6463 |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj-art-c5dfa93d452e4c28bcacbbfc783c64632025-08-20T02:53:17ZengMDPI AGLife2075-17292024-12-011412162910.3390/life14121629Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based TherapiesManal M. Khowdiary0Zinab Alatawi1Amirah Alhowiti2Mohamed A. Amin3Hussam Daghistani4Faisal Miqad K. Albaqami5Mohamed Ali Abdel-Rahman6Ahmed Ghareeb7Nehad A. Shaer8Ahmed M. Shawky9Amr Fouda10Department of Chemistry, Faculty of Applied Science, Lieth Collage, Umm Al-Qura University, Makkah 24382, Saudi ArabiaDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk 47512, Saudi ArabiaDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk 47512, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaBiology Department, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptBotany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia 41522, EgyptDepartment of Chemistry, Faculty of Applied Science, Lieth Collage, Umm Al-Qura University, Makkah 24382, Saudi ArabiaScience and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptThis study examined the phytochemical profile and biomedical activities of <i>Nitraria retusa</i>, a halophytic and drought-resistant shrub. HPLC analysis showed gallic acid (1905.1 μg/g), catechin (1984.1 μg/g), and ellagic acid (2671.1 μg/g) as the primary constituents, while FT-IR analysis revealed a complex organic profile with significant functional groups. The extract demonstrated strong antioxidant activity in DPPH assays, outperforming ascorbic acid (IC<sub>50</sub> = 18.7 ± 1.0 μg/mL) with an IC<sub>50</sub> of 16.4 ± 4.4 μg/mL. It demonstrated specific antiproliferative effects on cancer cell lines as it showed selective cytotoxicity against cancer cell lines; normal WI38 cells were largely unaffected, showing 50.0% viability at 125 μg/mL. The most sensitive cell line was Caco2, which showed 50.0% viability at 125 μg/mL. Anti-diabetic properties were exhibited by means of inhibition of α-amylase (IC<sub>50</sub> = 68.2 ± 4.2 μg/mL) and α-glucosidase (IC<sub>50</sub> = 22.8 ± 3.3 μg/mL). Additionally, antimicrobial activity was observed to be broad-spectrum, and it was most effective against <i>E. coli</i> (32.6 mm inhibition zone at 400 μg/mL) and <i>Penicillium glabrum</i> (35.3 mm at 400 μg/mL). These findings highlight the potential of <i>N. retusa</i> in developing plant-based therapeutic approaches.https://www.mdpi.com/2075-1729/14/12/1629plant extracts<i>Nitraria retusa</i>antioxidant activitycytotoxicityanti-diabeticantimicrobial activity |
| spellingShingle | Manal M. Khowdiary Zinab Alatawi Amirah Alhowiti Mohamed A. Amin Hussam Daghistani Faisal Miqad K. Albaqami Mohamed Ali Abdel-Rahman Ahmed Ghareeb Nehad A. Shaer Ahmed M. Shawky Amr Fouda Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies Life plant extracts <i>Nitraria retusa</i> antioxidant activity cytotoxicity anti-diabetic antimicrobial activity |
| title | Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies |
| title_full | Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies |
| title_fullStr | Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies |
| title_full_unstemmed | Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies |
| title_short | Phytochemical Analysis and Multifaceted Biomedical Activities of <i>Nitraria retusa</i> Extract as Natural Product-Based Therapies |
| title_sort | phytochemical analysis and multifaceted biomedical activities of i nitraria retusa i extract as natural product based therapies |
| topic | plant extracts <i>Nitraria retusa</i> antioxidant activity cytotoxicity anti-diabetic antimicrobial activity |
| url | https://www.mdpi.com/2075-1729/14/12/1629 |
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