Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis
Along with affecting oral health, oral microbial communities may also be endogenously translocated to the gut, thereby mediating the development of a range of malignancies in that habitat. While species-level studies have proven the capability of oral pathogens to migrate to the intestine, genetic e...
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MDPI AG
2024-10-01
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| author | Linqi Wang Qinyu Wang Yan Zhou |
| author_facet | Linqi Wang Qinyu Wang Yan Zhou |
| author_sort | Linqi Wang |
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| description | Along with affecting oral health, oral microbial communities may also be endogenously translocated to the gut, thereby mediating the development of a range of malignancies in that habitat. While species-level studies have proven the capability of oral pathogens to migrate to the intestine, genetic evidence supporting this mechanism remains insufficient. In this study, we identified over 55,000 oral translocation genes (OTGs) associated with colorectal cancer (CRC) and inflammatory bowel disease (IBD). These genes are primarily involved in signal transduction and cell wall biosynthesis and show consistency in their functions between IBD and CRC. Furthermore, we found that <i>Leclercia adecarboxylata</i>, a newly discovered opportunistic pathogen, has a significantly high abundance in the gut microbiota of colorectal cancer patients. OTGs of this pathogen were enriched in 15 metabolic pathways, including those associated with amino acid and cofactor metabolism. These findings, for the first time, provide evidence at the genetic level of the transfer of oral pathogens to the intestine and offer new insights into the understanding of the roles of oral pathogens in the development of gastrointestinal cancers. |
| format | Article |
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| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-10-01 |
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| series | Microorganisms |
| spelling | doaj-art-c5da64cb19bf4fe0a1ee7663ce36d3952025-08-20T02:11:00ZengMDPI AGMicroorganisms2076-26072024-10-011210208610.3390/microorganisms12102086Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic AnalysisLinqi Wang0Qinyu Wang1Yan Zhou2State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, ChinaAlong with affecting oral health, oral microbial communities may also be endogenously translocated to the gut, thereby mediating the development of a range of malignancies in that habitat. While species-level studies have proven the capability of oral pathogens to migrate to the intestine, genetic evidence supporting this mechanism remains insufficient. In this study, we identified over 55,000 oral translocation genes (OTGs) associated with colorectal cancer (CRC) and inflammatory bowel disease (IBD). These genes are primarily involved in signal transduction and cell wall biosynthesis and show consistency in their functions between IBD and CRC. Furthermore, we found that <i>Leclercia adecarboxylata</i>, a newly discovered opportunistic pathogen, has a significantly high abundance in the gut microbiota of colorectal cancer patients. OTGs of this pathogen were enriched in 15 metabolic pathways, including those associated with amino acid and cofactor metabolism. These findings, for the first time, provide evidence at the genetic level of the transfer of oral pathogens to the intestine and offer new insights into the understanding of the roles of oral pathogens in the development of gastrointestinal cancers.https://www.mdpi.com/2076-2607/12/10/2086metagenomicsoral pathogencolorectal cancerinflammatory bowel diseaseoral-gut axis |
| spellingShingle | Linqi Wang Qinyu Wang Yan Zhou Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis Microorganisms metagenomics oral pathogen colorectal cancer inflammatory bowel disease oral-gut axis |
| title | Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis |
| title_full | Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis |
| title_fullStr | Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis |
| title_full_unstemmed | Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis |
| title_short | Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis |
| title_sort | oral microbial translocation genes in gastrointestinal cancers insights from metagenomic analysis |
| topic | metagenomics oral pathogen colorectal cancer inflammatory bowel disease oral-gut axis |
| url | https://www.mdpi.com/2076-2607/12/10/2086 |
| work_keys_str_mv | AT linqiwang oralmicrobialtranslocationgenesingastrointestinalcancersinsightsfrommetagenomicanalysis AT qinyuwang oralmicrobialtranslocationgenesingastrointestinalcancersinsightsfrommetagenomicanalysis AT yanzhou oralmicrobialtranslocationgenesingastrointestinalcancersinsightsfrommetagenomicanalysis |