Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis
<p> S.I. Zhukova<sup>1</sup>, D.Yu. Samsonov<sup>1</sup>, T.N. Yurieva<sup>1–3</sup>, T.V. Prozorova<sup>1</sup> </p> <p> <sup>1</sup>Irkutsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk,...
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| Language: | Russian |
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Prime-Media
2024-12-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/328/ry169apfofk5kdpqoahkt0yxchvwhzy8.pdf |
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| author | S.I. Zhukova D.Yu. Samsonov T.N. Yur’eva T.V. Prozorova |
| author_facet | S.I. Zhukova D.Yu. Samsonov T.N. Yur’eva T.V. Prozorova |
| author_sort | S.I. Zhukova |
| collection | DOAJ |
| description | <p>
S.I. Zhukova<sup>1</sup>, D.Yu. Samsonov<sup>1</sup>, T.N. Yurieva<sup>1–3</sup>, T.V. Prozorova<sup>1</sup>
</p>
<p>
<sup>1</sup>Irkutsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk, Russian Federation
</p>
<p>
<sup>2</sup>Irkutsk State Medical Academy of Professional Education — Branch of the Russian Medical Academy of Continuous Professional Education, Irkutsk, Russian Federation
</p>
<p>
<sup>3</sup>Irkutsk State Medical University, Irkutsk, Russian Federation
</p>
<p>
<b>Background: </b>although thinning of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) revealed by optical coherence tomography (OCT) are nonspecific data, they represent a key link in pathogenesis of optic neuropathy (ON) regardless of etiology.
</p>
<p>
<b>Aim: </b>to identify differences between OCT patterns of RNFL and GCC damages associated with ON of different genesis.
</p>
<p>
<b>Patients and Methods: </b>еxamination data of 58 patients with a suspected or preliminary diagnosed glaucoma who underwent an ophthalmic examination in a glaucoma department were retrospectively analyzed. According to the findings, 2 groups were formed. A Group 1 included 19 patients with an initial stage of primary open-angle glaucoma. 12 patients with altered RNFL and GCC, ineligible for glaucoma ON (GON), were enrolled in a non-glaucoma ON (non-GON) group. As a result of a detailed analysis of complaints, systemic and neurological status, chronic non-arteritic ischemic ON was diagnosed in 5 patients of the Group 2. In 7 patients, ON was associated with a history of optic neuritis with underlying multiple sclerosis (MS). Thus, we are faced with ONs associated with glaucoma, ischemia and MS. Considering a fundamentally different approach to treatment of these diseases and relevance of their differential diagnosis, a comparative analysis of ganglion cell axon topography was carried out in 3 groups in the light of the medical condition (1 — glaucoma-associated lesions, 2 — ischemia-associated lesions, 3 — MS-associated lesions).
</p>
<p>
<b>Results: </b>the most pronounced RNFL alterations were observed in lower and temporal quadrants (GON patients); upper and nasal quadrants (ischemia patients); and in a temporal quadrant (MS patients). Retinal GCC lesions associated with GON and ischemia were asymmetric (superior defects in glaucoma patients vs. inferior defects in ischemia ones). MS-associated macular lesions were symmetrical and outstripped the RNFL alterations.
</p>
<p>
<b>Conclusion:</b> different patterns of peripapillary RNFL and macular GCC damages are caused by pathogenesis of primary neuronal damage. These differences can be used as differential diagnostic criteria for GON and non-GON conditions in routine clinical practice.
</p>
<p>
<b>Keywords</b>: optical coherence tomography, peripapillary retinal nerve fiber layer, macular ganglion cell complex, glaucoma ischemic optic neuropathy, non-arterial ischemic opticopathy, retrobulbar neuritis, multiple sclerosis.
</p>
<p>
<b>For citation:</b> Zhukova S.I., Samsonov D.Yu., Yurieva T.N., Prozorova T.V. Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis. Russian Journal of Clinical Ophthalmology. 2024;24(4):170–176 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-2
</p> |
| format | Article |
| id | doaj-art-c5d7e2d665eb4b40b23798343fd0937a |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-c5d7e2d665eb4b40b23798343fd0937a2025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712024-12-0124431791Optical coherence tomography in differential diagnosis of optic neuropathy of various genesisS.I. Zhukova0D.Yu. Samsonov1T.N. Yur’eva2T.V. Prozorova3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> S.I. Zhukova<sup>1</sup>, D.Yu. Samsonov<sup>1</sup>, T.N. Yurieva<sup>1–3</sup>, T.V. Prozorova<sup>1</sup> </p> <p> <sup>1</sup>Irkutsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk, Russian Federation </p> <p> <sup>2</sup>Irkutsk State Medical Academy of Professional Education — Branch of the Russian Medical Academy of Continuous Professional Education, Irkutsk, Russian Federation </p> <p> <sup>3</sup>Irkutsk State Medical University, Irkutsk, Russian Federation </p> <p> <b>Background: </b>although thinning of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) revealed by optical coherence tomography (OCT) are nonspecific data, they represent a key link in pathogenesis of optic neuropathy (ON) regardless of etiology. </p> <p> <b>Aim: </b>to identify differences between OCT patterns of RNFL and GCC damages associated with ON of different genesis. </p> <p> <b>Patients and Methods: </b>еxamination data of 58 patients with a suspected or preliminary diagnosed glaucoma who underwent an ophthalmic examination in a glaucoma department were retrospectively analyzed. According to the findings, 2 groups were formed. A Group 1 included 19 patients with an initial stage of primary open-angle glaucoma. 12 patients with altered RNFL and GCC, ineligible for glaucoma ON (GON), were enrolled in a non-glaucoma ON (non-GON) group. As a result of a detailed analysis of complaints, systemic and neurological status, chronic non-arteritic ischemic ON was diagnosed in 5 patients of the Group 2. In 7 patients, ON was associated with a history of optic neuritis with underlying multiple sclerosis (MS). Thus, we are faced with ONs associated with glaucoma, ischemia and MS. Considering a fundamentally different approach to treatment of these diseases and relevance of their differential diagnosis, a comparative analysis of ganglion cell axon topography was carried out in 3 groups in the light of the medical condition (1 — glaucoma-associated lesions, 2 — ischemia-associated lesions, 3 — MS-associated lesions). </p> <p> <b>Results: </b>the most pronounced RNFL alterations were observed in lower and temporal quadrants (GON patients); upper and nasal quadrants (ischemia patients); and in a temporal quadrant (MS patients). Retinal GCC lesions associated with GON and ischemia were asymmetric (superior defects in glaucoma patients vs. inferior defects in ischemia ones). MS-associated macular lesions were symmetrical and outstripped the RNFL alterations. </p> <p> <b>Conclusion:</b> different patterns of peripapillary RNFL and macular GCC damages are caused by pathogenesis of primary neuronal damage. These differences can be used as differential diagnostic criteria for GON and non-GON conditions in routine clinical practice. </p> <p> <b>Keywords</b>: optical coherence tomography, peripapillary retinal nerve fiber layer, macular ganglion cell complex, glaucoma ischemic optic neuropathy, non-arterial ischemic opticopathy, retrobulbar neuritis, multiple sclerosis. </p> <p> <b>For citation:</b> Zhukova S.I., Samsonov D.Yu., Yurieva T.N., Prozorova T.V. Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis. Russian Journal of Clinical Ophthalmology. 2024;24(4):170–176 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-2 </p>http://clinopht.com/upload/iblock/328/ry169apfofk5kdpqoahkt0yxchvwhzy8.pdf |
| spellingShingle | S.I. Zhukova D.Yu. Samsonov T.N. Yur’eva T.V. Prozorova Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis РМЖ "Клиническая офтальмология" |
| title | Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| title_full | Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| title_fullStr | Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| title_full_unstemmed | Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| title_short | Optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| title_sort | optical coherence tomography in differential diagnosis of optic neuropathy of various genesis |
| url | http://clinopht.com/upload/iblock/328/ry169apfofk5kdpqoahkt0yxchvwhzy8.pdf |
| work_keys_str_mv | AT sizhukova opticalcoherencetomographyindifferentialdiagnosisofopticneuropathyofvariousgenesis AT dyusamsonov opticalcoherencetomographyindifferentialdiagnosisofopticneuropathyofvariousgenesis AT tnyureva opticalcoherencetomographyindifferentialdiagnosisofopticneuropathyofvariousgenesis AT tvprozorova opticalcoherencetomographyindifferentialdiagnosisofopticneuropathyofvariousgenesis |