Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint disease

Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint disease

Abstract Chikungunya virus (CHIKV) infection often results in a chronic joint condition known as Post-Chikungunya Chronic Inflammatory Joint Disease (pCHIKV-CIJD). This condition disrupts individuals’ daily lives and contributes to increased healthcare expenditure. This study investigated the molecu...

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Main Authors: Mariana Severo Ramundo, Guilherme Cordenonsi da Fonseca, Felipe Ten-Caten, Alexandra L. Gerber, Ana Paula Guimarães, Erika Regina Manuli, Marina Farrel Côrtes, Geovana Maria Pereira, Otavio Brustolini, Milena Gomes Cabral, Carolina Dos Santos Lázari, Patrícia Brasil, Clarisse da Silveira Bressan, Helder I. Nakaya, Gláucia Paranhos-Baccalà, Ana Tereza R. Vasconcelos, Ester Cerdeira Sabino
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
CHIKV
Chikungunya
Post-Chikungunya Chronic Inflammatory Joint Disease
Total RNA sequencing
Small RNA sequencing
Chikungunya prognosis
Online Access:https://doi.org/10.1038/s41598-025-86761-x
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