International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan
Introduction Robotic-assisted surgery (RAS) has emerged as an alternative minimally invasive surgical option. Despite its growing applicability, the frequent need for pneumoperitoneum and Trendelenburg position could significantly affect respiratory mechanics during RAS. AVATaR is an international m...
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2018-08-01
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| author | Toby N Weingarten Idit Matot Gary H Mills Marcus J Schultz Vijaya Gottumukkala Ary Serpa Neto Lee-Lynn Chen Paolo Pelosi Marcelo Gama de Abreu Veronica Neves Fialho Queiroz Luiz Guilherme Villares da Costa Rogerio Póvoa Barbosa Flávio Takaoka Luc De Baerdemaeker Daniel Souza Cesar Ulisses Cardoso D’Orto José Roberto Galdi Juan P Cata Sabrine N T Hemmes Markus W Hollman Alain Kalmar Lucas A B de Moura Renato M Mariano Guido Mazzinari Irimar de Paula Posso Alexandre Teruya Marcos Francisco Vidal Melo Juraj Sprung Tanja A Treschan Seppe Koopman Leonid Eidelman Jae-Woo Lee Jose J Ariño Irujo Beatriz Tena Harald Groeben |
| author_facet | Toby N Weingarten Idit Matot Gary H Mills Marcus J Schultz Vijaya Gottumukkala Ary Serpa Neto Lee-Lynn Chen Paolo Pelosi Marcelo Gama de Abreu Veronica Neves Fialho Queiroz Luiz Guilherme Villares da Costa Rogerio Póvoa Barbosa Flávio Takaoka Luc De Baerdemaeker Daniel Souza Cesar Ulisses Cardoso D’Orto José Roberto Galdi Juan P Cata Sabrine N T Hemmes Markus W Hollman Alain Kalmar Lucas A B de Moura Renato M Mariano Guido Mazzinari Irimar de Paula Posso Alexandre Teruya Marcos Francisco Vidal Melo Juraj Sprung Tanja A Treschan Seppe Koopman Leonid Eidelman Jae-Woo Lee Jose J Ariño Irujo Beatriz Tena Harald Groeben |
| author_sort | Toby N Weingarten |
| collection | DOAJ |
| description | Introduction Robotic-assisted surgery (RAS) has emerged as an alternative minimally invasive surgical option. Despite its growing applicability, the frequent need for pneumoperitoneum and Trendelenburg position could significantly affect respiratory mechanics during RAS. AVATaR is an international multicenter observational study aiming to assess the incidence of postoperative pulmonary complications (PPC), to characterise current practices of mechanical ventilation (MV) and to evaluate a possible association between ventilatory parameters and PPC in patients undergoing RAS.Methods and analysis AVATaR is an observational study of surgical patients undergoing MV for general anaesthesia for RAS. The primary outcome is the incidence of PPC during the first five postoperative days. Secondary outcomes include practice of MV, effect of surgical positioning on MV, effect of MV on clinical outcome and intraoperative complications.Ethics and dissemination This study was approved by the Institutional Review Board of the Hospital Israelita Albert Einstein. The study results will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number NCT02989415; Pre-results. |
| format | Article |
| id | doaj-art-c5d1d384124c4b28a45e37b246753095 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2018-08-01 |
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| spelling | doaj-art-c5d1d384124c4b28a45e37b2467530952025-08-20T01:48:14ZengBMJ Publishing GroupBMJ Open2044-60552018-08-018810.1136/bmjopen-2018-021643International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis planToby N Weingarten0Idit Matot1Gary H Mills2Marcus J Schultz3Vijaya Gottumukkala4Ary Serpa Neto5Lee-Lynn Chen6Paolo Pelosi7Marcelo Gama de Abreu8Veronica Neves Fialho Queiroz9Luiz Guilherme Villares da Costa10Rogerio Póvoa Barbosa11Flávio Takaoka12Luc De Baerdemaeker13Daniel Souza Cesar14Ulisses Cardoso D’Orto15José Roberto Galdi16Juan P Cata17Sabrine N T Hemmes18Markus W Hollman19Alain Kalmar20Lucas A B de Moura21Renato M Mariano22Guido Mazzinari23Irimar de Paula Posso24Alexandre Teruya25Marcos Francisco Vidal Melo26Juraj Sprung27Tanja A Treschan28Seppe Koopman29Leonid Eidelman30Jae-Woo Lee31Jose J Ariño Irujo32Beatriz Tena33Harald Groeben3413 Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA8 Division of Anesthesiology, Intensive Care and Pain, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel4 Anaesthesia and Critical Care Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK7 University of Amsterdam, Academic Medical Center Department of Intensive Care Medicine, Amsterdam, Noord-Holland, Netherlands4 Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology and Critical Care, University of Texas MD Anderson Cancer Center, Houston, Texas, USAAustralian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, AustraliaDepartment of Anesthesiology, University of California San Francisco, San Francisco, California, USA21 Department of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology, University of Genoa, Genoa, Italy22 Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil2 Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, BrazilDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center Department of Anesthesiology and Perioperative Medicine, Houston, Texas, USA4 Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands6 Department of Anesthesiology, Amsterdam University Medical Center, Duivendrecht, Noord-Holland, The Netherlands6 Department of Anesthesia and Intensive Care Medicine, Maria Middelares Hospital, Ghent, Belgium1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Perioperative Medicine Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil1 Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil12 Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA1 Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA14 Department of Anesthesiology, Düsseldorf University Hospital, Medical Faculty of Heinrich-Heine University, Düsseldorf, GermanyDepartment of Anaesthesiology, Maasstad Ziekenhuis, Rotterdam, The NetherlandsFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel17 Department of Anesthesia and Perioperative Care, University of California-San Francisco, San Francisco, California, USA18 Department of Anesthesia, Hospital Clínico San Carlos, Madrid, SpainAnaesthesiology and Intensive Care, Hospital Clinic de Barcelona, Barcelona, Spain20 Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Kliniken Essen-Mitte, Essen, GermanyIntroduction Robotic-assisted surgery (RAS) has emerged as an alternative minimally invasive surgical option. Despite its growing applicability, the frequent need for pneumoperitoneum and Trendelenburg position could significantly affect respiratory mechanics during RAS. AVATaR is an international multicenter observational study aiming to assess the incidence of postoperative pulmonary complications (PPC), to characterise current practices of mechanical ventilation (MV) and to evaluate a possible association between ventilatory parameters and PPC in patients undergoing RAS.Methods and analysis AVATaR is an observational study of surgical patients undergoing MV for general anaesthesia for RAS. The primary outcome is the incidence of PPC during the first five postoperative days. Secondary outcomes include practice of MV, effect of surgical positioning on MV, effect of MV on clinical outcome and intraoperative complications.Ethics and dissemination This study was approved by the Institutional Review Board of the Hospital Israelita Albert Einstein. The study results will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number NCT02989415; Pre-results.https://bmjopen.bmj.com/content/8/8/e021643.full |
| spellingShingle | Toby N Weingarten Idit Matot Gary H Mills Marcus J Schultz Vijaya Gottumukkala Ary Serpa Neto Lee-Lynn Chen Paolo Pelosi Marcelo Gama de Abreu Veronica Neves Fialho Queiroz Luiz Guilherme Villares da Costa Rogerio Póvoa Barbosa Flávio Takaoka Luc De Baerdemaeker Daniel Souza Cesar Ulisses Cardoso D’Orto José Roberto Galdi Juan P Cata Sabrine N T Hemmes Markus W Hollman Alain Kalmar Lucas A B de Moura Renato M Mariano Guido Mazzinari Irimar de Paula Posso Alexandre Teruya Marcos Francisco Vidal Melo Juraj Sprung Tanja A Treschan Seppe Koopman Leonid Eidelman Jae-Woo Lee Jose J Ariño Irujo Beatriz Tena Harald Groeben International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan BMJ Open |
| title | International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan |
| title_full | International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan |
| title_fullStr | International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan |
| title_full_unstemmed | International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan |
| title_short | International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan |
| title_sort | international multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication avatar study protocol and statistical analysis plan |
| url | https://bmjopen.bmj.com/content/8/8/e021643.full |
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