Myasthenia gravis complicated by Graves’ disease: a case report
Abstract Introduction Myasthenia gravis is a neuromuscular autoimmune condition characterized by the presence of antibodies against acetylcholine receptors. It may present as a generalized disorder or remain limited to specific muscle groups. Myasthenia gravis can occur independently or alongside ot...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-025-05198-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Introduction Myasthenia gravis is a neuromuscular autoimmune condition characterized by the presence of antibodies against acetylcholine receptors. It may present as a generalized disorder or remain limited to specific muscle groups. Myasthenia gravis can occur independently or alongside other autoimmune conditions, including Hashimoto’s thyroiditis and Graves’ disease. Although the co-occurrence of these disorders is recognized, it is an extremely rare clinical phenomenon. Case presentation A 20-year-old woman of Muganda ethnicity, with a 2-year history of Graves’ disease confirmed by thyroid scintigraphy, developed a myasthenic syndrome leading to acute respiratory failure. Her condition improved with the administration of Prostigmine. Further investigations, including electrophysiological studies and immunological tests, confirmed a diagnosis of myasthenia gravis. The patient demonstrated a positive response to medical therapy. Conclusion This case highlights the importance of recognizing the rare association between myasthenia gravis and Graves’ disease. Accurate diagnosis and effective treatment require a coordinated, multidisciplinary approach, particularly given the challenges posed by overlapping symptoms and the exacerbating effects of hyperthyroidism on myasthenia gravis. |
|---|---|
| ISSN: | 1752-1947 |