The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival

The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival

IntroductionUpon antigen recognition, naive CD8 T cells must induce c-JUN N-terminal kinase (JNK), NF-κB, and Akt signaling to drive differentiation and generate a heterogeneous effector response. While the roles of these three pathways individually in mediating essential cellular responses for CD8...

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Bibliographic Details
Main Authors: Caitlyn Guldenpfennig, Yue Guan, Bela Cseri, Elida Lopez, Emma Teixeiro, Mark Daniels
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
POSH
short-lived effector cell
memory precursors
signal transduction
NF-κB
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630599/full
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