Necroptosis in cancer: An angel or a demon?
In the past few decades, apoptosis has been regarded as the only form of programmed cell death. However, the traditional view has been challenged by the identification of several forms of regulated necrosis, including necroptosis. Necroptosis is typified by a necrotic cell death morphology and is co...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317711539 |
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| _version_ | 1849397532275245056 |
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| author | Tianzhen Wang Yinji Jin Weiwei Yang Lei Zhang Xiaoming Jin Xi Liu Yan He Xiaobo Li |
| author_facet | Tianzhen Wang Yinji Jin Weiwei Yang Lei Zhang Xiaoming Jin Xi Liu Yan He Xiaobo Li |
| author_sort | Tianzhen Wang |
| collection | DOAJ |
| description | In the past few decades, apoptosis has been regarded as the only form of programmed cell death. However, the traditional view has been challenged by the identification of several forms of regulated necrosis, including necroptosis. Necroptosis is typified by a necrotic cell death morphology and is controlled by RIP1, RIP3, and mixed lineage kinase domain–like protein. The physiological role of necroptosis is to serve as a “fail-safe” form of cell death for cells that fail to undergo apoptosis during embryonic development and disease defense. Currently, established studies have indicated that necroptosis is involved in cancer initiation and progression. Although elevated necroptosis contributes to cancer cell death, extensive cell death also increases the risk of proliferation and metastasis of the surviving cells by inducing the generation reactive oxygen species, activation of inflammation, and suppression of the immune response. Thus, questions regarding the overall impact of necroptosis on cancer remain open. In this review, we introduce the basic knowledge regarding necroptosis, summarize its dual effects on cancer progression, and analyze its advantages and disadvantages in clinical applications. |
| format | Article |
| id | doaj-art-c5c3c8653b3242078aeb0afdb6c0f565 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-c5c3c8653b3242078aeb0afdb6c0f5652025-08-20T03:38:58ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317711539Necroptosis in cancer: An angel or a demon?Tianzhen Wang0Yinji Jin1Weiwei Yang2Lei Zhang3Xiaoming Jin4Xi Liu5Yan He6Xiaobo Li7Department of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Cardiovascular, Inner Mongolia People’s Hospital, Hohhot, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaDepartment of Pathology, Harbin Medical University, Harbin, ChinaIn the past few decades, apoptosis has been regarded as the only form of programmed cell death. However, the traditional view has been challenged by the identification of several forms of regulated necrosis, including necroptosis. Necroptosis is typified by a necrotic cell death morphology and is controlled by RIP1, RIP3, and mixed lineage kinase domain–like protein. The physiological role of necroptosis is to serve as a “fail-safe” form of cell death for cells that fail to undergo apoptosis during embryonic development and disease defense. Currently, established studies have indicated that necroptosis is involved in cancer initiation and progression. Although elevated necroptosis contributes to cancer cell death, extensive cell death also increases the risk of proliferation and metastasis of the surviving cells by inducing the generation reactive oxygen species, activation of inflammation, and suppression of the immune response. Thus, questions regarding the overall impact of necroptosis on cancer remain open. In this review, we introduce the basic knowledge regarding necroptosis, summarize its dual effects on cancer progression, and analyze its advantages and disadvantages in clinical applications.https://doi.org/10.1177/1010428317711539 |
| spellingShingle | Tianzhen Wang Yinji Jin Weiwei Yang Lei Zhang Xiaoming Jin Xi Liu Yan He Xiaobo Li Necroptosis in cancer: An angel or a demon? Tumor Biology |
| title | Necroptosis in cancer: An angel or a demon? |
| title_full | Necroptosis in cancer: An angel or a demon? |
| title_fullStr | Necroptosis in cancer: An angel or a demon? |
| title_full_unstemmed | Necroptosis in cancer: An angel or a demon? |
| title_short | Necroptosis in cancer: An angel or a demon? |
| title_sort | necroptosis in cancer an angel or a demon |
| url | https://doi.org/10.1177/1010428317711539 |
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