Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population
Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. Material and methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) w...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-04-01
|
| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217308033 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850178668917161984 |
|---|---|
| author | Xiaoyan Gao Fei Ma Hu Hao Yiheng Dai Weidong Liu Xin Xiao Pingmin Gao Sitao Li |
| author_facet | Xiaoyan Gao Fei Ma Hu Hao Yiheng Dai Weidong Liu Xin Xiao Pingmin Gao Sitao Li |
| author_sort | Xiaoyan Gao |
| collection | DOAJ |
| description | Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. Material and methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay. Results: The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC. Conclusion: Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future. Key Words: necrotizing enterocolitis, preterm infants, single-nucleotide polymorphism, VEGFA |
| format | Article |
| id | doaj-art-c5c2cd3b331a46edb9627456e88781a1 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-c5c2cd3b331a46edb9627456e88781a12025-08-20T02:18:39ZengElsevierPediatrics and Neonatology1875-95722019-04-0160212913410.1016/j.pedneo.2018.07.002Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han populationXiaoyan Gao0Fei Ma1Hu Hao2Yiheng Dai3Weidong Liu4Xin Xiao5Pingmin Gao6Sitao Li7Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, ChinaDepartment of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Corresponding author. Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Yuancun Erheng Road, Tianhe District, Guangzhou, 510655, China, Fax: +86 0 20 3877 7850.Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China; Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China; Corresponding author. Foshan Institute of Fetal Medicine, Southern Medical University, Affiliated Maternal and Child Health Hospital of Foshan, No. 11 Renmin, West Road, Chancheng District, Foshan, 528000, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Corresponding author. Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Yuancun Erheng Road, Tianhe District, Guangzhou, 510655, China.Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. Material and methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay. Results: The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC. Conclusion: Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future. Key Words: necrotizing enterocolitis, preterm infants, single-nucleotide polymorphism, VEGFAhttp://www.sciencedirect.com/science/article/pii/S1875957217308033 |
| spellingShingle | Xiaoyan Gao Fei Ma Hu Hao Yiheng Dai Weidong Liu Xin Xiao Pingmin Gao Sitao Li Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population Pediatrics and Neonatology |
| title | Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population |
| title_full | Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population |
| title_fullStr | Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population |
| title_full_unstemmed | Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population |
| title_short | Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population |
| title_sort | association of vegfa polymorphisms with necrotizing enterocolitis in chinese han population |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217308033 |
| work_keys_str_mv | AT xiaoyangao associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT feima associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT huhao associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT yihengdai associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT weidongliu associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT xinxiao associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT pingmingao associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation AT sitaoli associationofvegfapolymorphismswithnecrotizingenterocolitisinchinesehanpopulation |