Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study
Background: Despite a lack of sufficient knowledge about the prevalence and impact of hypophosphatemia in critically ill COVID-19 patients, organ dysfunction, adverse clinical outcomes, and increased mortality have been consistently associated with hypophosphatemia across diverse patient populations...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502330T.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849737326339555328 |
|---|---|
| author | Temel Şahin Hanci Pervin Hakkı Akbudak Ismail Halaçli Burçin Güven Göksel Bilir Yeliz Civan Yüksel Recep Özyilmaz Ezgi Altintaş Neriman Defne Ferliçolak Leyla Aydin Emre Akbaş Türkay Esbah Ali Ümit Güllü Zuhal Inci Kamil Elay Gülseren Topeli Arzu Gündoğan Kürşat |
| author_facet | Temel Şahin Hanci Pervin Hakkı Akbudak Ismail Halaçli Burçin Güven Göksel Bilir Yeliz Civan Yüksel Recep Özyilmaz Ezgi Altintaş Neriman Defne Ferliçolak Leyla Aydin Emre Akbaş Türkay Esbah Ali Ümit Güllü Zuhal Inci Kamil Elay Gülseren Topeli Arzu Gündoğan Kürşat |
| author_sort | Temel Şahin |
| collection | DOAJ |
| description | Background: Despite a lack of sufficient knowledge about the prevalence and impact of hypophosphatemia in critically ill COVID-19 patients, organ dysfunction, adverse clinical outcomes, and increased mortality have been consistently associated with hypophosphatemia across diverse patient populations. This retrospective, observational study aimed to investigate hypophosphatemia (HypoP) frequency and establish the correlation between variations in serum phosphorus levels and outcomes in critically ill patients with SARS-CoV-2. Methods: The research comprised 205 patients diagnosed with COVID-19 confirmed via RT-PCR. The study included COVID-19 patients who experienced respiratory failure and were in intensive care for more than 24 hours, and their phosphorus values were accurately documented. Clinical para meters, comorbidities, respiratory support requirements, and laboratory findings were analysed. Results: The study participants had a median age of 64 (IQR: 54-75 years), with hypertension being the most pre - valent chronic disease (46%). During the first three days of intensive care, 33% of the participants received conventional oxygen support, whereas 54% required intubation and mechanical ventilation (MV). During this period, hypophosphatemia was noted in 25% of patients, with an ICU admission median serum phosphorus level of 1.02 (0.87-1.25) mmol/L. The median duration of stay in the intensive care unit (ICU) was 7 days, significantly extended in patients with hypophosphatemia (p=0.046). Phosphorus levels on the third day of ICU stay were an independent predictor of ICU mortality. (COX, HR=1.48, 95% CI=1.11-1.98, p=0.006) Conclusions: During the first three days of ICU admission, 25% of SARS-CoV-2 critically ill adult patients presented with hypophosphatemia. This condition was found to increase ICU mortality rates and prolong ICU stays. Therefore, it is crucial to monitor serum phosphorus levels in the care of critically ill COVID-19 patients. |
| format | Article |
| id | doaj-art-c5bfcfd65c144d3886229d0615b83cbe |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-c5bfcfd65c144d3886229d0615b83cbe2025-08-20T03:06:57ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144233033810.5937/jomb0-524741452-82582502330THypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational studyTemel Şahin0Hanci Pervin1Hakkı Akbudak Ismail2Halaçli Burçin3Güven Göksel4Bilir Yeliz5Civan Yüksel Recep6Özyilmaz Ezgi7Altintaş Neriman Defne8Ferliçolak Leyla9Aydin Emre10Akbaş Türkay11Esbah Ali Ümit12Güllü Zuhal13Inci Kamil14Elay Gülseren15Topeli Arzu16Gündoğan Kürşat17Erciyes University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Kayseri, TurkeyTrakya University, School of Medicine, Department of Chest Diseases, Division of Intensive Care Medicine, Edirne, TurkeyPamukkale University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Denizli, TurkeyHacettepe University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Ankara, TurkeyHacettepe University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Ankara, TurkeyMinistry of Health, Istanbul Lütfi Kırdar Training and Research Hospital, Intensive Unit, Istanbul, TurkeyErciyes University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Kayseri, TurkeyÇukurova University School of Medicine, Department of Chest Diseases, Division of Intensive Care Medicine, Adana, TurkeyAnkara University School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Ankara, TurkeyAnkara University School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Ankara, TurkeyDicle University School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Diyarbakır, TurkeyDüzce University School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Düzce, TurkeyDüzce University School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Düzce, TurkeyAnkara Yenimahalle Training and Research Hospital, Intensive Care Unit, Ministry of Health, Ankara, TurkeyAnkara Yenimahalle Training and Research Hospital, Intensive Care Unit, Ministry of Health, Ankara, TurkeyGaziantep University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Gaziantep, TurkeyHacettepe University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Ankara, TurkeyErciyes University, School of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, Kayseri, TurkeyBackground: Despite a lack of sufficient knowledge about the prevalence and impact of hypophosphatemia in critically ill COVID-19 patients, organ dysfunction, adverse clinical outcomes, and increased mortality have been consistently associated with hypophosphatemia across diverse patient populations. This retrospective, observational study aimed to investigate hypophosphatemia (HypoP) frequency and establish the correlation between variations in serum phosphorus levels and outcomes in critically ill patients with SARS-CoV-2. Methods: The research comprised 205 patients diagnosed with COVID-19 confirmed via RT-PCR. The study included COVID-19 patients who experienced respiratory failure and were in intensive care for more than 24 hours, and their phosphorus values were accurately documented. Clinical para meters, comorbidities, respiratory support requirements, and laboratory findings were analysed. Results: The study participants had a median age of 64 (IQR: 54-75 years), with hypertension being the most pre - valent chronic disease (46%). During the first three days of intensive care, 33% of the participants received conventional oxygen support, whereas 54% required intubation and mechanical ventilation (MV). During this period, hypophosphatemia was noted in 25% of patients, with an ICU admission median serum phosphorus level of 1.02 (0.87-1.25) mmol/L. The median duration of stay in the intensive care unit (ICU) was 7 days, significantly extended in patients with hypophosphatemia (p=0.046). Phosphorus levels on the third day of ICU stay were an independent predictor of ICU mortality. (COX, HR=1.48, 95% CI=1.11-1.98, p=0.006) Conclusions: During the first three days of ICU admission, 25% of SARS-CoV-2 critically ill adult patients presented with hypophosphatemia. This condition was found to increase ICU mortality rates and prolong ICU stays. Therefore, it is crucial to monitor serum phosphorus levels in the care of critically ill COVID-19 patients.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502330T.pdfsars-cov-2hypophosphatemiaintensive care unitrespiratory failurecritical care |
| spellingShingle | Temel Şahin Hanci Pervin Hakkı Akbudak Ismail Halaçli Burçin Güven Göksel Bilir Yeliz Civan Yüksel Recep Özyilmaz Ezgi Altintaş Neriman Defne Ferliçolak Leyla Aydin Emre Akbaş Türkay Esbah Ali Ümit Güllü Zuhal Inci Kamil Elay Gülseren Topeli Arzu Gündoğan Kürşat Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study Journal of Medical Biochemistry sars-cov-2 hypophosphatemia intensive care unit respiratory failure critical care |
| title | Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study |
| title_full | Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study |
| title_fullStr | Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study |
| title_full_unstemmed | Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study |
| title_short | Hypophosphatemia: Unraveling a lethal connection with icu mortality in critically ill COVID-19 patients: a multicenter observational study |
| title_sort | hypophosphatemia unraveling a lethal connection with icu mortality in critically ill covid 19 patients a multicenter observational study |
| topic | sars-cov-2 hypophosphatemia intensive care unit respiratory failure critical care |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502330T.pdf |
| work_keys_str_mv | AT temelsahin hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT hancipervin hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT hakkıakbudakismail hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT halacliburcin hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT guvengoksel hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT biliryeliz hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT civanyukselrecep hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT ozyilmazezgi hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT altintasnerimandefne hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT ferlicolakleyla hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT aydinemre hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT akbasturkay hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT esbahaliumit hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT gulluzuhal hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT incikamil hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT elaygulseren hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT topeliarzu hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy AT gundogankursat hypophosphatemiaunravelingalethalconnectionwithicumortalityincriticallyillcovid19patientsamulticenterobservationalstudy |