Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy
Abstract Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type‐II PDT, which is highly dependent...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Smart Molecules |
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| Online Access: | https://doi.org/10.1002/smo.20240037 |
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| author | Shibo Lyu Lukun Li Jingdong Gao Dapeng Liu Fengling Song |
| author_facet | Shibo Lyu Lukun Li Jingdong Gao Dapeng Liu Fengling Song |
| author_sort | Shibo Lyu |
| collection | DOAJ |
| description | Abstract Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type‐II PDT, which is highly dependent on oxygen. Here type‐I photosensitizer BTZn‐Py (n = 8, 20) coordinates with chemical antibacterial agent Ag+ to fabricate metallo‐supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type‐II reactive oxygen species (ROS), 1O2, but also produce type‐I ROS O2•− which addressed the hypoxic issues within infected tissues. Moreover, the acid‐ and photo‐active Ag+ release from the nanofibers endowed the metallo‐supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag+ release and photoinduced type‐I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo‐supramolecular fibers against both Gram‐positive and Gram‐negative bacteria. |
| format | Article |
| id | doaj-art-c5b8fdee197c4028aab1c8369a3fbf0a |
| institution | DOAJ |
| issn | 2751-4587 2751-4595 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Smart Molecules |
| spelling | doaj-art-c5b8fdee197c4028aab1c8369a3fbf0a2025-08-20T02:52:16ZengWileySmart Molecules2751-45872751-45952024-12-0124n/an/a10.1002/smo.20240037Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapyShibo Lyu0Lukun Li1Jingdong Gao2Dapeng Liu3Fengling Song4Institute of Frontier Chemistry School of Chemistry and Chemical Engineering Shandong University Qingdao ChinaInstitute of Frontier Chemistry School of Chemistry and Chemical Engineering Shandong University Qingdao ChinaSchool of Life Sciences Shandong University Qingdao Shandong ChinaInstitute of Frontier Chemistry School of Chemistry and Chemical Engineering Shandong University Qingdao ChinaInstitute of Frontier Chemistry School of Chemistry and Chemical Engineering Shandong University Qingdao ChinaAbstract Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type‐II PDT, which is highly dependent on oxygen. Here type‐I photosensitizer BTZn‐Py (n = 8, 20) coordinates with chemical antibacterial agent Ag+ to fabricate metallo‐supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type‐II reactive oxygen species (ROS), 1O2, but also produce type‐I ROS O2•− which addressed the hypoxic issues within infected tissues. Moreover, the acid‐ and photo‐active Ag+ release from the nanofibers endowed the metallo‐supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag+ release and photoinduced type‐I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo‐supramolecular fibers against both Gram‐positive and Gram‐negative bacteria.https://doi.org/10.1002/smo.20240037antibacterial therapymetallo‐supramoleculartype‐I photodynamic therapy |
| spellingShingle | Shibo Lyu Lukun Li Jingdong Gao Dapeng Liu Fengling Song Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy Smart Molecules antibacterial therapy metallo‐supramolecular type‐I photodynamic therapy |
| title | Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy |
| title_full | Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy |
| title_fullStr | Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy |
| title_full_unstemmed | Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy |
| title_short | Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy |
| title_sort | metallo supramolecular nanofibers based on type i photosensitizer for synergistic antibacterial therapy |
| topic | antibacterial therapy metallo‐supramolecular type‐I photodynamic therapy |
| url | https://doi.org/10.1002/smo.20240037 |
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