Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy
Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging and efficient therapeutic capabilities. In t...
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| Format: | Article |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202416905 |
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| author | Haiqiao Huang Yingnan Wu Xin He Yahang Liu Jing‐Hui Zhu Mingrui Gu Danhong Zhou Saran Long Yahui Chen Lei Wang Mingle Li Xiaoqiang Chen Xiaojun Peng |
| author_facet | Haiqiao Huang Yingnan Wu Xin He Yahang Liu Jing‐Hui Zhu Mingrui Gu Danhong Zhou Saran Long Yahui Chen Lei Wang Mingle Li Xiaoqiang Chen Xiaojun Peng |
| author_sort | Haiqiao Huang |
| collection | DOAJ |
| description | Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self‐assembly of two cyanines, C5TNa (anionic) and Cy‐Et (cationic). The Coulombic interactions between C5TNa and Cy‐Et facilitate the formation of a complementary cyanine pair (C5T‐ET) and the creation of supramolecular CT‐J‐type aggregates in water. This complementary cyanine pair (C5T‐ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3‐fold increase in photothermal conversion efficiency and a 7.1‐fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J‐type aggregate cyanine pair (C5T‐ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T‐ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J‐aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo. |
| format | Article |
| id | doaj-art-c5b445c6d7ec4629a4c4f7f7c2fa13db |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-c5b445c6d7ec4629a4c4f7f7c2fa13db2025-08-20T01:51:39ZengWileyAdvanced Science2198-38442025-04-011213n/an/a10.1002/advs.202416905Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal TherapyHaiqiao Huang0Yingnan Wu1Xin He2Yahang Liu3Jing‐Hui Zhu4Mingrui Gu5Danhong Zhou6Saran Long7Yahui Chen8Lei Wang9Mingle Li10Xiaoqiang Chen11Xiaojun Peng12College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaState Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 P. R. ChinaState Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaCollege of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. ChinaAbstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self‐assembly of two cyanines, C5TNa (anionic) and Cy‐Et (cationic). The Coulombic interactions between C5TNa and Cy‐Et facilitate the formation of a complementary cyanine pair (C5T‐ET) and the creation of supramolecular CT‐J‐type aggregates in water. This complementary cyanine pair (C5T‐ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3‐fold increase in photothermal conversion efficiency and a 7.1‐fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J‐type aggregate cyanine pair (C5T‐ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T‐ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J‐aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo.https://doi.org/10.1002/advs.202416905co‐assemblycyanine pairj aggregatesphotothermal therapyphotoacoustic imaging |
| spellingShingle | Haiqiao Huang Yingnan Wu Xin He Yahang Liu Jing‐Hui Zhu Mingrui Gu Danhong Zhou Saran Long Yahui Chen Lei Wang Mingle Li Xiaoqiang Chen Xiaojun Peng Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy Advanced Science co‐assembly cyanine pair j aggregates photothermal therapy photoacoustic imaging |
| title | Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy |
| title_full | Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy |
| title_fullStr | Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy |
| title_full_unstemmed | Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy |
| title_short | Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy |
| title_sort | electrostatic co assembly of cyanine pair for augmented photoacoustic imaging and photothermal therapy |
| topic | co‐assembly cyanine pair j aggregates photothermal therapy photoacoustic imaging |
| url | https://doi.org/10.1002/advs.202416905 |
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