Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs
Chronic kidney disease (CKD) is the most commonly diagnosed renal condition in dogs, having a gradual and irreversible course. In this context, the present study aimed to evaluate the efficacy of a nutritional supplement containing calcium carbonate, vitamin D3, and chitosan, administered over a 60-...
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Kafkas University, Faculty of Veterinary Medicine
2025-08-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=3213 |
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| author | Florin Dan SIMIZ Elena Daniela BRĂSLAȘU Cristina VĂDUVA |
| author_facet | Florin Dan SIMIZ Elena Daniela BRĂSLAȘU Cristina VĂDUVA |
| author_sort | Florin Dan SIMIZ |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is the most commonly diagnosed renal condition in
dogs, having a gradual and irreversible course. In this context, the present study aimed
to evaluate the efficacy of a nutritional supplement containing calcium carbonate,
vitamin D3, and chitosan, administered over a 60-day period to a group of 20 mixedbreed
dogs (10 females and 10 males), aged between 8 and 12 years, diagnosed with
CKD stages 1, 2 and 3, according to the IRIS classification. Supplement administration
resulted in significant changes in hematological and biochemical parameters: a 4.14%
increase in red blood cell count, a 34.18% increase in total serum protein concentration
and a 55.18% increase in albumin levels. Concurrently, marked decreases were observed
in key renal dysfunction markers: phosphorus (-53.7%), creatinine (-75.54%), SDMA
(-48.1%), and urea (-71.7%). Pulsed Doppler ultrasound revealed a 48.6% reduction
in the renal resistive index (RRI), suggesting improved renal perfusion. In addition to
these favorable biochemical effects, clinical improvements were also reported, including
reduced polyuria and polydipsia, increased appetite, and enhanced general health status.
These findings suggest that the tested supplement may play a beneficial role in slowing
CKD progression and supporting the metabolic and clinical condition of affected dogs,
indicating promising therapeutic potential as an adjuvant in the management of this
disease. |
| format | Article |
| id | doaj-art-c5b18c3be37148d2a260ee5a3d11de50 |
| institution | Kabale University |
| issn | 1309-2251 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj-art-c5b18c3be37148d2a260ee5a3d11de502025-08-20T03:46:16ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512025-08-0131450751610.9775/kvfd.2025.341833213Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogsFlorin Dan SIMIZ0Elena Daniela BRĂSLAȘU1Cristina VĂDUVA2University of Life Sciences ”King Mihai I” from Timisoara, Faculty of Veterinary Medicine, Department Internal Medicine, 300645 Timisoara, ROMANIAUniversity of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, Department Internal Medicine, 050097 Bucharest, ROMANIAUniversity of Life Sciences ”King Mihai I” from Timisoara, Faculty of Veterinary Medicine, Department Internal Medicine, 300645 Timisoara, ROMANIAChronic kidney disease (CKD) is the most commonly diagnosed renal condition in dogs, having a gradual and irreversible course. In this context, the present study aimed to evaluate the efficacy of a nutritional supplement containing calcium carbonate, vitamin D3, and chitosan, administered over a 60-day period to a group of 20 mixedbreed dogs (10 females and 10 males), aged between 8 and 12 years, diagnosed with CKD stages 1, 2 and 3, according to the IRIS classification. Supplement administration resulted in significant changes in hematological and biochemical parameters: a 4.14% increase in red blood cell count, a 34.18% increase in total serum protein concentration and a 55.18% increase in albumin levels. Concurrently, marked decreases were observed in key renal dysfunction markers: phosphorus (-53.7%), creatinine (-75.54%), SDMA (-48.1%), and urea (-71.7%). Pulsed Doppler ultrasound revealed a 48.6% reduction in the renal resistive index (RRI), suggesting improved renal perfusion. In addition to these favorable biochemical effects, clinical improvements were also reported, including reduced polyuria and polydipsia, increased appetite, and enhanced general health status. These findings suggest that the tested supplement may play a beneficial role in slowing CKD progression and supporting the metabolic and clinical condition of affected dogs, indicating promising therapeutic potential as an adjuvant in the management of this disease.https://vetdergikafkas.org/pdf.php?id=3213calcium carbonatechitosanchronic kidney diseasedogsdoppler ultrasoundvitamin d3 |
| spellingShingle | Florin Dan SIMIZ Elena Daniela BRĂSLAȘU Cristina VĂDUVA Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs Kafkas Universitesi Veteriner Fakültesi Dergisi calcium carbonate chitosan chronic kidney disease dogs doppler ultrasound vitamin d3 |
| title | Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| title_full | Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| title_fullStr | Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| title_full_unstemmed | Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| title_short | Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| title_sort | clinical and paraclinical assessment of the efficacy of calcium carbonate vitamin d3 and chitosan in the management of chronic renal failure in dogs |
| topic | calcium carbonate chitosan chronic kidney disease dogs doppler ultrasound vitamin d3 |
| url | https://vetdergikafkas.org/pdf.php?id=3213 |
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