β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy

β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy

Abstract Background In perinatal dairy cows, ketosis is a prevalent metabolic disorder that lowers milk output and performance. Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood ketone levels, particularly β-hydroxybutyrate (BHB). Recent research has l...

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Bibliographic Details
Main Authors: Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Autophagy
Bovine mammary gland
Inflammation
Mitochondria DNA
Online Access:https://doi.org/10.1186/s40104-024-01143-z
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