Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage
Doxorubicin (DOX), a commonly used ant-cancer drug, has its clinical application severely restricted due to its serious cardiotoxic side-effects. Adenylyl cyclase 1 (ADCY1) is recognized for its pivotal role in cardiac pathophysiology. Nonetheless, the involvement of ADCY1 in DOX-induced cardiotoxic...
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01014.pdf |
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| author | Zhang Le Li Xin Zhang Qingwen Li Yanfei |
| author_facet | Zhang Le Li Xin Zhang Qingwen Li Yanfei |
| author_sort | Zhang Le |
| collection | DOAJ |
| description | Doxorubicin (DOX), a commonly used ant-cancer drug, has its clinical application severely restricted due to its serious cardiotoxic side-effects. Adenylyl cyclase 1 (ADCY1) is recognized for its pivotal role in cardiac pathophysiology. Nonetheless, the involvement of ADCY1 in DOX-induced cardiotoxicity (DIC) remains not well-studied. This study aimed to elucidate the role of ADCY1 in DIC, in particular whether ADCY1 affects oxidative stress and myocardial injury. Our findings indicate that ADCY1 expression is downregulated in DOX-treatment AC16 cardiomyocytes with a DOX concentration- dependent manner. Silencing of ADCY1 further exacerbated DIC. It was manifested by the elevated levels of ANP, BNP, LDH oxidative stress compared with DOX treatment group. Conversely, over expression of ADCY1 mitigated these adverse effects induced by DOX. Our study elucidates the cardioprotective effects of ADCY1 by attenuating DOX-induced myocardial injury, oxidative stress . It provides a novel perspective for the development of therapeutic strategies aimed at reducing cardiac toxicity in patients undergoing DOX treatment. |
| format | Article |
| id | doaj-art-c5aae9b70c6047778c116dee655a1c71 |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-c5aae9b70c6047778c116dee655a1c712025-08-20T02:26:01ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011740101410.1051/bioconf/202517401014bioconf_icbb2025_01014Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damageZhang Le0Li Xin1Zhang Qingwen2Li Yanfei3Graduate School, Shanghai University of Traditional Chinese MedicinePhysical Examination Center, Shanghai East Hospital, Tongji University School of MedicineShanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalShanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalDoxorubicin (DOX), a commonly used ant-cancer drug, has its clinical application severely restricted due to its serious cardiotoxic side-effects. Adenylyl cyclase 1 (ADCY1) is recognized for its pivotal role in cardiac pathophysiology. Nonetheless, the involvement of ADCY1 in DOX-induced cardiotoxicity (DIC) remains not well-studied. This study aimed to elucidate the role of ADCY1 in DIC, in particular whether ADCY1 affects oxidative stress and myocardial injury. Our findings indicate that ADCY1 expression is downregulated in DOX-treatment AC16 cardiomyocytes with a DOX concentration- dependent manner. Silencing of ADCY1 further exacerbated DIC. It was manifested by the elevated levels of ANP, BNP, LDH oxidative stress compared with DOX treatment group. Conversely, over expression of ADCY1 mitigated these adverse effects induced by DOX. Our study elucidates the cardioprotective effects of ADCY1 by attenuating DOX-induced myocardial injury, oxidative stress . It provides a novel perspective for the development of therapeutic strategies aimed at reducing cardiac toxicity in patients undergoing DOX treatment.https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01014.pdf |
| spellingShingle | Zhang Le Li Xin Zhang Qingwen Li Yanfei Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage BIO Web of Conferences |
| title | Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| title_full | Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| title_fullStr | Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| title_full_unstemmed | Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| title_short | Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| title_sort | adenylyl cyclase 1 mitigates doxorubicin induced cardiotoxicity by reducing oxidative stress and myocardial damage |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01014.pdf |
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