Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.

Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.

The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus providing an attractive target for imaging the proliferative status (i.e., P:Q ratio) of solid tumors. Here we evaluate the utility of the sigma-2 receptor ligand 2-(2-[(18)F]f...

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Bibliographic Details
Main Authors: Kooresh I Shoghi, Jinbin Xu, Yi Su, June He, Douglas Rowland, Ying Yan, Joel R Garbow, Zhude Tu, Lynne A Jones, Ryuji Higashikubo, Kenneth T Wheeler, Ronald A Lubet, Robert H Mach, Ming You
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0074188
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