Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant

Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant

Lassa virus (LASV) glycoprotein complex (GPC) contains retained stable-signal peptide (SSP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2). Through serial passaging of LASV with inhibitors, adaptive mutants were obtained, most of which had mutations in the transmembrane (TM) domain of GP2. Characte...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiao Guo, Yalan Du, Guangshun Zhang, Yang Liu, Junyuan Cao, Mengmeng Zhang, Xiaohao Lan, Yueli Zhang, Chenchen Liu, Gengfu Xiao, Wei Wang
Format: Article
Language:English
Published: Compuscript Ltd 2025-01-01
Series:Zoonoses
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0051
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items