Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease
Abstract Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This study analyzed data from 501,483 participants, including...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01098-6 |
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| _version_ | 1849226527607095296 |
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| author | Kaitai Yang Ruitian Zeng Yiling Zheng Siqi Zhong Jiani Wang Xinxi Yu Huilin Zhong Xuanjie Chen Yisen Shi Fabin Lin Qinyong Ye Ning Sun Guoen Cai |
| author_facet | Kaitai Yang Ruitian Zeng Yiling Zheng Siqi Zhong Jiani Wang Xinxi Yu Huilin Zhong Xuanjie Chen Yisen Shi Fabin Lin Qinyong Ye Ning Sun Guoen Cai |
| author_sort | Kaitai Yang |
| collection | DOAJ |
| description | Abstract Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This study analyzed data from 501,483 participants, including 907 PD cases. Cox models revealed that digestive diseases were significantly associated with an increased PD risk (HR = 1.43). Eleven digestive diseases were linked to PD, with lifestyle factors such as sleep patterns and diet reducing PD risk. Notably, interactions between Non-alcoholic Fatty Liver Disease (NAFLD) and sleep (P-int = 0.0119), and Crohn’s disease and dietary diversity (P-int = 0.0081) were observed. Population attributable fraction (PAF) analysis indicated that eliminating exposure to gastroesophageal reflux disease (GERD), gastritis and duodenitis, and gallbladder and biliary diseases could reduce PD cases by approximately 8.9%, 7.9%, and 3.8%, respectively. These findings emphasize the role of digestive diseases and lifestyle in PD risk. |
| format | Article |
| id | doaj-art-c59a14ed73424abe829f031e674f8b2c |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-c59a14ed73424abe829f031e674f8b2c2025-08-24T11:14:45ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-0111111010.1038/s41531-025-01098-6Associations of digestive diseases exposure and lifestyle factors with Parkinson’s diseaseKaitai Yang0Ruitian Zeng1Yiling Zheng2Siqi Zhong3Jiani Wang4Xinxi Yu5Huilin Zhong6Xuanjie Chen7Yisen Shi8Fabin Lin9Qinyong Ye10Ning Sun11Guoen Cai12Department of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Neurosurgery, Fujian Medical University Union HospitalDepartment of Neurology, Fujian Medical University Union HospitalDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Neurology, Fujian Medical University Union HospitalAbstract Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This study analyzed data from 501,483 participants, including 907 PD cases. Cox models revealed that digestive diseases were significantly associated with an increased PD risk (HR = 1.43). Eleven digestive diseases were linked to PD, with lifestyle factors such as sleep patterns and diet reducing PD risk. Notably, interactions between Non-alcoholic Fatty Liver Disease (NAFLD) and sleep (P-int = 0.0119), and Crohn’s disease and dietary diversity (P-int = 0.0081) were observed. Population attributable fraction (PAF) analysis indicated that eliminating exposure to gastroesophageal reflux disease (GERD), gastritis and duodenitis, and gallbladder and biliary diseases could reduce PD cases by approximately 8.9%, 7.9%, and 3.8%, respectively. These findings emphasize the role of digestive diseases and lifestyle in PD risk.https://doi.org/10.1038/s41531-025-01098-6 |
| spellingShingle | Kaitai Yang Ruitian Zeng Yiling Zheng Siqi Zhong Jiani Wang Xinxi Yu Huilin Zhong Xuanjie Chen Yisen Shi Fabin Lin Qinyong Ye Ning Sun Guoen Cai Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease npj Parkinson's Disease |
| title | Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease |
| title_full | Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease |
| title_fullStr | Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease |
| title_full_unstemmed | Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease |
| title_short | Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease |
| title_sort | associations of digestive diseases exposure and lifestyle factors with parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-01098-6 |
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