Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children
The impact of obesity as a systemic low-grade inflammatory process has only partially been explored. To this effect, 704 community-based school-aged children (354 obese children and 350 age-, gender-, and ethnicity-matched controls) were recruited and underwent assessment of plasma levels of fasting...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2010/846098 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849744141607501824 |
|---|---|
| author | Jinkwan Kim Rakesh Bhattacharjee Leila Kheirandish-Gozal Abdelnaby Khalyfa Oscar Sans Capdevila Riva Tauman David Gozal |
| author_facet | Jinkwan Kim Rakesh Bhattacharjee Leila Kheirandish-Gozal Abdelnaby Khalyfa Oscar Sans Capdevila Riva Tauman David Gozal |
| author_sort | Jinkwan Kim |
| collection | DOAJ |
| description | The impact of obesity as a systemic low-grade inflammatory process has only partially been explored. To this effect, 704 community-based school-aged children (354 obese children and 350 age-, gender-, and ethnicity-matched controls) were recruited and underwent assessment of plasma levels of fasting insulin and glucose, lipids, and a variety of proinflammatory mediators that are associated with cardiometabolic dysfunction. Obese children were at higher risk for abnormal HOMA and cholesterol levels. Furthermore, BMI z score, HOMA, and LDL/HDL ratio strongly correlated with levels of certain inflammatory mediators. Taken together, obesity in children is not only associated with insulin resistance and hyperlipidemia, but is accompanied by increased, yet variable, expression of markers of systemic inflammation. Future community-based intervention and phenotype correlational studies on childhood obesity will require inclusion of expanded panels of inflammatory biomarkers to provide a comprehensive assessment of risk on specific obesity-related morbidities. |
| format | Article |
| id | doaj-art-c59918e894444286882973a286ec40b9 |
| institution | DOAJ |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-c59918e894444286882973a286ec40b92025-08-20T03:22:42ZengWileyInternational Journal of Pediatrics1687-97401687-97592010-01-01201010.1155/2010/846098846098Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese ChildrenJinkwan Kim0Rakesh Bhattacharjee1Leila Kheirandish-Gozal2Abdelnaby Khalyfa3Oscar Sans Capdevila4Riva Tauman5David Gozal6Department of Pediatrics, Comer Children's Hospital, The University of Chicago, Suite K-160, 5721, Maryland Avenue, MC 8000, Chicago, IL 60637, USADivision of Sleep and Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, CanadaDepartment of Pediatrics, Comer Children's Hospital, The University of Chicago, Suite K-160, 5721, Maryland Avenue, MC 8000, Chicago, IL 60637, USADepartment of Pediatrics, Comer Children's Hospital, The University of Chicago, Suite K-160, 5721, Maryland Avenue, MC 8000, Chicago, IL 60637, USAPediatric Sleep Unit, Division of Neurophysiology, Department of Neurology, Hospital Sant Joan de Déu, 08950 Barcelona, SpainDana Children's Hospital, Tel-Aviv University School of Medicine, Tel-Aviv 64239, IsraelDepartment of Pediatrics, Comer Children's Hospital, The University of Chicago, Suite K-160, 5721, Maryland Avenue, MC 8000, Chicago, IL 60637, USAThe impact of obesity as a systemic low-grade inflammatory process has only partially been explored. To this effect, 704 community-based school-aged children (354 obese children and 350 age-, gender-, and ethnicity-matched controls) were recruited and underwent assessment of plasma levels of fasting insulin and glucose, lipids, and a variety of proinflammatory mediators that are associated with cardiometabolic dysfunction. Obese children were at higher risk for abnormal HOMA and cholesterol levels. Furthermore, BMI z score, HOMA, and LDL/HDL ratio strongly correlated with levels of certain inflammatory mediators. Taken together, obesity in children is not only associated with insulin resistance and hyperlipidemia, but is accompanied by increased, yet variable, expression of markers of systemic inflammation. Future community-based intervention and phenotype correlational studies on childhood obesity will require inclusion of expanded panels of inflammatory biomarkers to provide a comprehensive assessment of risk on specific obesity-related morbidities.http://dx.doi.org/10.1155/2010/846098 |
| spellingShingle | Jinkwan Kim Rakesh Bhattacharjee Leila Kheirandish-Gozal Abdelnaby Khalyfa Oscar Sans Capdevila Riva Tauman David Gozal Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children International Journal of Pediatrics |
| title | Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children |
| title_full | Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children |
| title_fullStr | Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children |
| title_full_unstemmed | Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children |
| title_short | Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children |
| title_sort | insulin sensitivity serum lipids and systemic inflammatory markers in school aged obese and nonobese children |
| url | http://dx.doi.org/10.1155/2010/846098 |
| work_keys_str_mv | AT jinkwankim insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT rakeshbhattacharjee insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT leilakheirandishgozal insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT abdelnabykhalyfa insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT oscarsanscapdevila insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT rivatauman insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren AT davidgozal insulinsensitivityserumlipidsandsystemicinflammatorymarkersinschoolagedobeseandnonobesechildren |