NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY

"Neuroinflammation is an inflammatory process that occurs in the central nervous system (CNS), including the brain and spinal cord. It can be triggered by various conditions such as traumatic injuries, infections, neurodegenerative diseases (e.g., Alzheimer's or Parkinson's), autoimmu...

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Main Authors: Vlad Hartie, Maria Comănescu, Emilia Patrascanu, Andrei Cucu, Lidia Cureniuc, Otilia Boișteanu, Mihaela Dana Turliuc
Format: Article
Language:English
Published: Romanian Society of Oral Rehabilitation 2025-06-01
Series:Romanian Journal of Oral Rehabilitation
Online Access:https://rjor.ro/neuroinflammation-in-acute-traumatic-brain-injury/
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author Vlad Hartie
Maria Comănescu
Emilia Patrascanu
Andrei Cucu
Lidia Cureniuc
Otilia Boișteanu
Mihaela Dana Turliuc
author_facet Vlad Hartie
Maria Comănescu
Emilia Patrascanu
Andrei Cucu
Lidia Cureniuc
Otilia Boișteanu
Mihaela Dana Turliuc
author_sort Vlad Hartie
collection DOAJ
description "Neuroinflammation is an inflammatory process that occurs in the central nervous system (CNS), including the brain and spinal cord. It can be triggered by various conditions such as traumatic injuries, infections, neurodegenerative diseases (e.g., Alzheimer's or Parkinson's), autoimmune disorders, or metabolic stress. In cases of acute traumatic brain injury, neuroinflammation is caused by the primary injury and can exacerbate the evolving tissue pathology. The cells involved in the primary brain injury initiate a series of pathological reactions that involve a response from the immune system. It is this immune response that initiates neuroinflammation and leads to pathological consequences over time. The immune response varies depending on the injury mechanism, the location of immune cells in the brain, as well as the affected individual. Understanding the signals that initiate neuroinflammation and the context in which they arise can be crucial for understanding the contributions of immune cells in both pathology and regeneration. This article aims to review a number of factors that could influence the behavior of immune cells following acute traumatic brain injuries and the role of Interleukin-6 in neuroinflammation."
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institution Kabale University
issn 2066-7000
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language English
publishDate 2025-06-01
publisher Romanian Society of Oral Rehabilitation
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series Romanian Journal of Oral Rehabilitation
spelling doaj-art-c5982cb6eecc4af59932370c3a95c43b2025-08-21T08:31:31ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612025-06-011721037104510.62610/RJOR.2025.2.17.93NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURYVlad Hartie0Maria Comănescu1Emilia Patrascanu2Andrei Cucu3Lidia Cureniuc4Otilia Boișteanu5Mihaela Dana Turliuc6”Gr. T. Popa” University of Medicine and Pharmacy, Iași”Gr. T. Popa” University of Medicine and Pharmacy, Iași”Gr. T. Popa” University of Medicine and Pharmacy, Iași”Prof. Dr. N. Oblu” Emergency Clinical Hospital, Iași”Gr. T. Popa” University of Medicine and Pharmacy, Iași”Gr. T. Popa” University of Medicine and Pharmacy, Iași”Gr. T. Popa” University of Medicine and Pharmacy, Iași"Neuroinflammation is an inflammatory process that occurs in the central nervous system (CNS), including the brain and spinal cord. It can be triggered by various conditions such as traumatic injuries, infections, neurodegenerative diseases (e.g., Alzheimer's or Parkinson's), autoimmune disorders, or metabolic stress. In cases of acute traumatic brain injury, neuroinflammation is caused by the primary injury and can exacerbate the evolving tissue pathology. The cells involved in the primary brain injury initiate a series of pathological reactions that involve a response from the immune system. It is this immune response that initiates neuroinflammation and leads to pathological consequences over time. The immune response varies depending on the injury mechanism, the location of immune cells in the brain, as well as the affected individual. Understanding the signals that initiate neuroinflammation and the context in which they arise can be crucial for understanding the contributions of immune cells in both pathology and regeneration. This article aims to review a number of factors that could influence the behavior of immune cells following acute traumatic brain injuries and the role of Interleukin-6 in neuroinflammation." https://rjor.ro/neuroinflammation-in-acute-traumatic-brain-injury/
spellingShingle Vlad Hartie
Maria Comănescu
Emilia Patrascanu
Andrei Cucu
Lidia Cureniuc
Otilia Boișteanu
Mihaela Dana Turliuc
NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
Romanian Journal of Oral Rehabilitation
title NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
title_full NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
title_fullStr NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
title_full_unstemmed NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
title_short NEUROINFLAMMATION IN ACUTE TRAUMATIC BRAIN INJURY
title_sort neuroinflammation in acute traumatic brain injury
url https://rjor.ro/neuroinflammation-in-acute-traumatic-brain-injury/
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AT mariacomanescu neuroinflammationinacutetraumaticbraininjury
AT emiliapatrascanu neuroinflammationinacutetraumaticbraininjury
AT andreicucu neuroinflammationinacutetraumaticbraininjury
AT lidiacureniuc neuroinflammationinacutetraumaticbraininjury
AT otiliaboisteanu neuroinflammationinacutetraumaticbraininjury
AT mihaeladanaturliuc neuroinflammationinacutetraumaticbraininjury