Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice

InstructionAccumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear. Because PCSK9 is mainly expressed in the liver and modulates lipid uptake...

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Bibliographic Details
Main Authors: Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
inflammation
MAPK
PCSK9 inhibitor
PCSK9 siRNA
Toll-like receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1528250/full
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