Foundation model-driven multimodal prognostic prediction in patients undergoing primary surgery for high-grade serous ovarian cancer
Abstract High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible pa...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-00900-1 |
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| Summary: | Abstract High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible patients across four centers, collecting clinical, MRI, and hematoxylin and eosin (H&E)-stained whole slide images (WSIs) data. Pre-trained radiological and pathological foundation models were employed for feature precoding. Subsequently, we introduced unimodal and cross-modal adaptive aggregation networks to comprehensively model the features derived from each modality. Our findings revealed that both unimodal and cross-modal FoMu models exhibited superior and stable predictive capabilities for overall survival (OS) and progression-free survival (PFS). In summary, our study successfully developed a FoMu model that effectively integrates multimodal data to assess the prognoses of HGSOC patients, highlighting its potential for improving individualized patient management and clinical decision-making in future applications. |
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| ISSN: | 2397-768X |