A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs

A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs

Abstract Background Topologically associating domains (TADs) are functional units that organize chromosomes into 3D structures of interacting chromatin, and play a crucial role in regulating gene expression by constraining enhancer-promoter contacts. Evidence suggests that deletion of TAD boundaries...

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Bibliographic Details
Main Authors: Hongwei Yin, Qianyi Zhao, Liu Yang, Guoqiang Yi, Wenye Yao, Lingzhao Fang, Lijing Bai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Pig
TADs
Gene expression
Biological functions
Online Access:https://doi.org/10.1186/s12864-025-11490-4
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