Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis
Background Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-inva...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e000813.full |
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| author | Daryl Cheng Claire Calderwood Erik Skyllberg Adam Ainley |
| author_facet | Daryl Cheng Claire Calderwood Erik Skyllberg Adam Ainley |
| author_sort | Daryl Cheng |
| collection | DOAJ |
| description | Background Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District General Hospitals across a large East London National Health Service Trust during the first wave of the pandemic.Methods A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or laboratory diagnosis of COVID-19, including descriptive statistics and survival analysis. A more detailed analysis was undertaken of a subset of patients admitted across three respiratory units in the trust.Results Increasing age, male sex and Asian ethnicity were associated with worse outcomes. Increasing severity of chest X-ray abnormalities trended with mortality. Radiological changes persisted in over 50% of cases at early follow-up (6 weeks). Ongoing symptoms including hair loss, memory impairment, breathlessness, cough and fatigue were reported in 70% of survivors, with 39% of patients unable to return to work due to ongoing symptoms.Conclusions Understanding the acute clinical features, course of illness and outcomes of COVID-19 will be crucial in understanding the effect of differences in risk, as well as the effectiveness of new interventions and vaccination between the successive waves of the pandemic. |
| format | Article |
| id | doaj-art-c591ee99021f414ea2c32bfa65040af2 |
| institution | Kabale University |
| issn | 2052-4439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-c591ee99021f414ea2c32bfa65040af22024-11-24T06:30:08ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-01-018110.1136/bmjresp-2020-000813Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysisDaryl Cheng0Claire Calderwood1Erik Skyllberg2Adam Ainley3UCL Respiratory, University College London, London, UKRespiratory Department, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UKRespiratory Medicine, Barts Health NHS Trust, London, UKRespiratory Department, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UKBackground Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District General Hospitals across a large East London National Health Service Trust during the first wave of the pandemic.Methods A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or laboratory diagnosis of COVID-19, including descriptive statistics and survival analysis. A more detailed analysis was undertaken of a subset of patients admitted across three respiratory units in the trust.Results Increasing age, male sex and Asian ethnicity were associated with worse outcomes. Increasing severity of chest X-ray abnormalities trended with mortality. Radiological changes persisted in over 50% of cases at early follow-up (6 weeks). Ongoing symptoms including hair loss, memory impairment, breathlessness, cough and fatigue were reported in 70% of survivors, with 39% of patients unable to return to work due to ongoing symptoms.Conclusions Understanding the acute clinical features, course of illness and outcomes of COVID-19 will be crucial in understanding the effect of differences in risk, as well as the effectiveness of new interventions and vaccination between the successive waves of the pandemic.https://bmjopenrespres.bmj.com/content/8/1/e000813.full |
| spellingShingle | Daryl Cheng Claire Calderwood Erik Skyllberg Adam Ainley Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis BMJ Open Respiratory Research |
| title | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| title_full | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| title_fullStr | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| title_full_unstemmed | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| title_short | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| title_sort | clinical characteristics and outcomes of adult patients admitted with covid 19 in east london a retrospective cohort analysis |
| url | https://bmjopenrespres.bmj.com/content/8/1/e000813.full |
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