Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement
Abstract Previous studies on serum albumin-to-globulin ratio (AGR) in human cancers were limited to its preoperative level, with postoperative serial AGR remeasurements ignored. In this study, 2844 CRC patients, 2267 NSCLC patients and 507 HCC patients who underwent curative resection were included....
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Nature Portfolio
2025-01-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-00809-9 |
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| author | Zhenhui Li Chunxia Li Ruimin You Yanli Li Lizhu Liu Hongjiang Pu Ming Lei Wenliang Li Tao Zhang Dingyun You |
| author_facet | Zhenhui Li Chunxia Li Ruimin You Yanli Li Lizhu Liu Hongjiang Pu Ming Lei Wenliang Li Tao Zhang Dingyun You |
| author_sort | Zhenhui Li |
| collection | DOAJ |
| description | Abstract Previous studies on serum albumin-to-globulin ratio (AGR) in human cancers were limited to its preoperative level, with postoperative serial AGR remeasurements ignored. In this study, 2844 CRC patients, 2267 NSCLC patients and 507 HCC patients who underwent curative resection were included. Postoperative AGR was a prognostic factor independent to preoperative AGR, performing a L shaped relation with OS. The 5-year OS rates for the persistently normal, normalized, lowered and persistently low perioperative AGR groups were 84.0%, 80.7%, 78.5% and 70.2%. Three longitudinal AGR trajectory groups were identified within 12 months after surgery. Compared with the normal-stable group, the adjusted HRs on OS for the rising-decreasing and decreasing-rising groups were 1.38 (95% CI: 1.13–1.68, P = 0.001) and 2.78 (95% CI: 2.30–3.36, P < 0.001). Similar results were observed for RFS. In conclusion, a routine follow-up of AGR in the postoperative surveillance will improve prognosis risk stratification of cancer patients. |
| format | Article |
| id | doaj-art-c58df72276b244efaf984bd0c4721d7f |
| institution | Kabale University |
| issn | 2397-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj-art-c58df72276b244efaf984bd0c4721d7f2025-01-26T12:12:56ZengNature Portfolionpj Precision Oncology2397-768X2025-01-01911710.1038/s41698-025-00809-9Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurementZhenhui Li0Chunxia Li1Ruimin You2Yanli Li3Lizhu Liu4Hongjiang Pu5Ming Lei6Wenliang Li7Tao Zhang8Dingyun You9Department of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Colorectal Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Clinical Laboratory Medicine, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Colorectal Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong UniversityYunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical UniversityAbstract Previous studies on serum albumin-to-globulin ratio (AGR) in human cancers were limited to its preoperative level, with postoperative serial AGR remeasurements ignored. In this study, 2844 CRC patients, 2267 NSCLC patients and 507 HCC patients who underwent curative resection were included. Postoperative AGR was a prognostic factor independent to preoperative AGR, performing a L shaped relation with OS. The 5-year OS rates for the persistently normal, normalized, lowered and persistently low perioperative AGR groups were 84.0%, 80.7%, 78.5% and 70.2%. Three longitudinal AGR trajectory groups were identified within 12 months after surgery. Compared with the normal-stable group, the adjusted HRs on OS for the rising-decreasing and decreasing-rising groups were 1.38 (95% CI: 1.13–1.68, P = 0.001) and 2.78 (95% CI: 2.30–3.36, P < 0.001). Similar results were observed for RFS. In conclusion, a routine follow-up of AGR in the postoperative surveillance will improve prognosis risk stratification of cancer patients.https://doi.org/10.1038/s41698-025-00809-9 |
| spellingShingle | Zhenhui Li Chunxia Li Ruimin You Yanli Li Lizhu Liu Hongjiang Pu Ming Lei Wenliang Li Tao Zhang Dingyun You Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement npj Precision Oncology |
| title | Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| title_full | Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| title_fullStr | Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| title_full_unstemmed | Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| title_short | Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| title_sort | longitudinal investigation of albumin to globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement |
| url | https://doi.org/10.1038/s41698-025-00809-9 |
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