Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer
Summary: Due to limited light penetration and dependence on oxygen, photodynamic therapy (PDT) is typically restricted to treating shallow tissues. Developing strategies to overcome these limitations and effectively using PDT for tumor treatment is a significant yet unresolved challenge. In this stu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225004572 |
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| author | Chengbin Yang Shiqi Tang Qiqi Liu Miaozhuang Fan Wenguang Zhang Yingyu Liu Xin Chen Gaixia Xu Xiaoyan Chen Zhourui Xu |
| author_facet | Chengbin Yang Shiqi Tang Qiqi Liu Miaozhuang Fan Wenguang Zhang Yingyu Liu Xin Chen Gaixia Xu Xiaoyan Chen Zhourui Xu |
| author_sort | Chengbin Yang |
| collection | DOAJ |
| description | Summary: Due to limited light penetration and dependence on oxygen, photodynamic therapy (PDT) is typically restricted to treating shallow tissues. Developing strategies to overcome these limitations and effectively using PDT for tumor treatment is a significant yet unresolved challenge. In this study, we present a smart approach combining a wireless-charged LED (wLED) with a type I aggregation-induced emission photosensitizer, MeOTTMN, to address both light penetration and tumor hypoxia issues simultaneously. MeOTTMN, characterized by twisted molecular architecture and strong intramolecular electron donor-acceptor interaction, produces high levels of hydroxyl and superoxide radicals and emits near-infrared light in its aggregated state, thus facilitating fluorescence imaging-guided PDT once formulated into nanoparticles. The inhibition of breast cancer xenografts provides compelling evidence of the treatment efficacy of type I PDT irradiated through an implantable wLED. This strategy provides a conceptual and practical paradigm to overcome key clinical limitations of PDT, expanding possibilities for clinical translation. |
| format | Article |
| id | doaj-art-c587ac0ae27c4f83a989d7fe36a93c7f |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-c587ac0ae27c4f83a989d7fe36a93c7f2025-08-20T02:49:20ZengElsevieriScience2589-00422025-04-0128411219610.1016/j.isci.2025.112196Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizerChengbin Yang0Shiqi Tang1Qiqi Liu2Miaozhuang Fan3Wenguang Zhang4Yingyu Liu5Xin Chen6Gaixia Xu7Xiaoyan Chen8Zhourui Xu9School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaMaternal-Fetal Medicine Institute, Department of Obstetics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen 518133, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, ChinaMaternal-Fetal Medicine Institute, Department of Obstetics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen 518133, China; Corresponding authorSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China; Corresponding authorSummary: Due to limited light penetration and dependence on oxygen, photodynamic therapy (PDT) is typically restricted to treating shallow tissues. Developing strategies to overcome these limitations and effectively using PDT for tumor treatment is a significant yet unresolved challenge. In this study, we present a smart approach combining a wireless-charged LED (wLED) with a type I aggregation-induced emission photosensitizer, MeOTTMN, to address both light penetration and tumor hypoxia issues simultaneously. MeOTTMN, characterized by twisted molecular architecture and strong intramolecular electron donor-acceptor interaction, produces high levels of hydroxyl and superoxide radicals and emits near-infrared light in its aggregated state, thus facilitating fluorescence imaging-guided PDT once formulated into nanoparticles. The inhibition of breast cancer xenografts provides compelling evidence of the treatment efficacy of type I PDT irradiated through an implantable wLED. This strategy provides a conceptual and practical paradigm to overcome key clinical limitations of PDT, expanding possibilities for clinical translation.http://www.sciencedirect.com/science/article/pii/S2589004225004572Materials in biotechnologyOptical propertyBiomaterials |
| spellingShingle | Chengbin Yang Shiqi Tang Qiqi Liu Miaozhuang Fan Wenguang Zhang Yingyu Liu Xin Chen Gaixia Xu Xiaoyan Chen Zhourui Xu Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer iScience Materials in biotechnology Optical property Biomaterials |
| title | Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer |
| title_full | Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer |
| title_fullStr | Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer |
| title_full_unstemmed | Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer |
| title_short | Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer |
| title_sort | wireless charging led mediated type i photodynamic therapy of breast cancer using nir aie photosensitizer |
| topic | Materials in biotechnology Optical property Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225004572 |
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