Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016)
Brominated flame retardants (BFRs) are environmental pollutants linked to health risks, including increased platelet (PLT) levels that may elevate the risk of thrombosis and cardiovascular diseases. This study examined the association between BFR exposure and PLT levels among 5831 adult participants...
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Elsevier
2024-12-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132401460X |
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| author | Shan-Shan Huang Yi Ding Hai-Yan Mao Shao-Feng Jin Mei-Xia Zheng Zhou-Xin Yang |
| author_facet | Shan-Shan Huang Yi Ding Hai-Yan Mao Shao-Feng Jin Mei-Xia Zheng Zhou-Xin Yang |
| author_sort | Shan-Shan Huang |
| collection | DOAJ |
| description | Brominated flame retardants (BFRs) are environmental pollutants linked to health risks, including increased platelet (PLT) levels that may elevate the risk of thrombosis and cardiovascular diseases. This study examined the association between BFR exposure and PLT levels among 5831 adult participants from the National Health and Nutrition Examination Survey (NHANES) (2007–2016). Of the 12 BFRs analyzed, BB153, BDE17, BDE85, BDE154, BDE183, and BDE209 showed significant positive correlations with PLT levels (p < 0.05), with BDE17 demonstrating the strongest correlation (Spearman’s coefficient = 0.122). After adjusting for confounders, all BFRs except BDE153 remained significantly associated with elevated PLT levels. Restricted cubic spline analysis indicated varying associations, with BDE99, BDE183, and BDE209 showing an ''S''-shaped relationship, while BB153, BDE17, and BDE66 presented an inverted ''J''-shaped relationship. BDE153 exhibited a ''U''-shaped relationship with PLT level. Both weighted quantile sum regression and quantile-based g-computation confirmed that BFR mixtures positively correlated with PLT levels, with BDE17 as the most significant contributor. Our findings suggest that BFR exposure is associated with increased PLT levels, indicating a potential risk for thrombosis and related cardiovascular conditions. |
| format | Article |
| id | doaj-art-c5838952a86c4083ae5edda24ff30ebd |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-c5838952a86c4083ae5edda24ff30ebd2025-08-20T02:37:28ZengElsevierEcotoxicology and Environmental Safety0147-65132024-12-0128811738410.1016/j.ecoenv.2024.117384Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016)Shan-Shan Huang0Yi Ding1Hai-Yan Mao2Shao-Feng Jin3Mei-Xia Zheng4Zhou-Xin Yang5Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, ChinaZhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310030, China; Corresponding author.Brominated flame retardants (BFRs) are environmental pollutants linked to health risks, including increased platelet (PLT) levels that may elevate the risk of thrombosis and cardiovascular diseases. This study examined the association between BFR exposure and PLT levels among 5831 adult participants from the National Health and Nutrition Examination Survey (NHANES) (2007–2016). Of the 12 BFRs analyzed, BB153, BDE17, BDE85, BDE154, BDE183, and BDE209 showed significant positive correlations with PLT levels (p < 0.05), with BDE17 demonstrating the strongest correlation (Spearman’s coefficient = 0.122). After adjusting for confounders, all BFRs except BDE153 remained significantly associated with elevated PLT levels. Restricted cubic spline analysis indicated varying associations, with BDE99, BDE183, and BDE209 showing an ''S''-shaped relationship, while BB153, BDE17, and BDE66 presented an inverted ''J''-shaped relationship. BDE153 exhibited a ''U''-shaped relationship with PLT level. Both weighted quantile sum regression and quantile-based g-computation confirmed that BFR mixtures positively correlated with PLT levels, with BDE17 as the most significant contributor. Our findings suggest that BFR exposure is associated with increased PLT levels, indicating a potential risk for thrombosis and related cardiovascular conditions.http://www.sciencedirect.com/science/article/pii/S014765132401460XBrominated flame retardantsElevated plateletThrombosisEnvironment healthCross-sectional analysis |
| spellingShingle | Shan-Shan Huang Yi Ding Hai-Yan Mao Shao-Feng Jin Mei-Xia Zheng Zhou-Xin Yang Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) Ecotoxicology and Environmental Safety Brominated flame retardants Elevated platelet Thrombosis Environment health Cross-sectional analysis |
| title | Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) |
| title_full | Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) |
| title_fullStr | Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) |
| title_full_unstemmed | Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) |
| title_short | Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007–2016) |
| title_sort | response of platelet count in the us population following exposure to bdes and bb a cross sectional analysis of database of nhanes 2007 2016 |
| topic | Brominated flame retardants Elevated platelet Thrombosis Environment health Cross-sectional analysis |
| url | http://www.sciencedirect.com/science/article/pii/S014765132401460X |
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