IDH1(R132H) Immunoexpression in Glioma
Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas. This study aimed to assess IDH1 immunoexpression in different types of gliomas and to...
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Kurdistan Higher Council Of Medical Specialties
2023-03-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/150 |
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| author | Nyan Saeed Omer Jalal Ali Jalal Ava Tahir Ismael |
| author_facet | Nyan Saeed Omer Jalal Ali Jalal Ava Tahir Ismael |
| author_sort | Nyan Saeed Omer |
| collection | DOAJ |
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Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas. This study aimed to assess IDH1 immunoexpression in different types of gliomas and to correlate the results with patient’s age, gender, tumor site, tumor type and grade.
Methods:During the period from January 2015 –January 2017, 97 cases of gliomas were collected from Rizgary Teaching Hospital and private laboratories in Erbil city. Typing and grading of tumors were done according to World Health Organization classification of brain tumors 2007.Immunohistochemical staining was done for IDH1 using monoclonal Antibody IDH1R132.
Results: Out of 97 cases of gliomas; 16 were grade I, 27 were grade II, 10 were anaplastic gliomas grade III and 44 cases were glioblastomas; grade IV. Positive IDH1 immunoex- pression was observed in 36 (37.1%) cases of gliomas. The highest prevalence of IDH1 was found in the age group 30-44 years (52.8%), in supratentorial tumors (44.3%) and in grade II and III astrocytoma (72.2% and 75%).Highly significant correlation was found between Isocitrate dehydrogenase 1 expression and age of the patients, tumor type and grade while a significant correlation was found between Isocitrate dehydrogenase 1 expression and tumor site.
Conclusions:Our study concluded that Isocitrate dehydrogenase 1 is 36 (37.1%) expressed in gliomas and it is sig- nificantly associated with patient’s age, tumor site, histological type and grade, thus it may act as a good diagnostic and prognostic marker for gliomas.
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| format | Article |
| id | doaj-art-c57dbb69988942d99b4c8f498c0f0b38 |
| institution | DOAJ |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-c57dbb69988942d99b4c8f498c0f0b382025-08-20T03:18:49ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802023-03-014110.56056/amj.2018.43151IDH1(R132H) Immunoexpression in GliomaNyan Saeed Omer0Jalal Ali Jalal 1Ava Tahir Ismael 2Department of Histopathology, Rizgary Teaching Hospital, Erbil. Department of Pathology, College of Medicine, HMU, Erbil.Department of Clinical Analysis, College of Pharmacy, HMU, Erbil Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas. This study aimed to assess IDH1 immunoexpression in different types of gliomas and to correlate the results with patient’s age, gender, tumor site, tumor type and grade. Methods:During the period from January 2015 –January 2017, 97 cases of gliomas were collected from Rizgary Teaching Hospital and private laboratories in Erbil city. Typing and grading of tumors were done according to World Health Organization classification of brain tumors 2007.Immunohistochemical staining was done for IDH1 using monoclonal Antibody IDH1R132. Results: Out of 97 cases of gliomas; 16 were grade I, 27 were grade II, 10 were anaplastic gliomas grade III and 44 cases were glioblastomas; grade IV. Positive IDH1 immunoex- pression was observed in 36 (37.1%) cases of gliomas. The highest prevalence of IDH1 was found in the age group 30-44 years (52.8%), in supratentorial tumors (44.3%) and in grade II and III astrocytoma (72.2% and 75%).Highly significant correlation was found between Isocitrate dehydrogenase 1 expression and age of the patients, tumor type and grade while a significant correlation was found between Isocitrate dehydrogenase 1 expression and tumor site. Conclusions:Our study concluded that Isocitrate dehydrogenase 1 is 36 (37.1%) expressed in gliomas and it is sig- nificantly associated with patient’s age, tumor site, histological type and grade, thus it may act as a good diagnostic and prognostic marker for gliomas. https://amj.khcms.edu.krd/index.php/main/article/view/150IDH1ImmunohistochemistryGlioma |
| spellingShingle | Nyan Saeed Omer Jalal Ali Jalal Ava Tahir Ismael IDH1(R132H) Immunoexpression in Glioma Advanced Medical Journal IDH1 Immunohistochemistry Glioma |
| title | IDH1(R132H) Immunoexpression in Glioma |
| title_full | IDH1(R132H) Immunoexpression in Glioma |
| title_fullStr | IDH1(R132H) Immunoexpression in Glioma |
| title_full_unstemmed | IDH1(R132H) Immunoexpression in Glioma |
| title_short | IDH1(R132H) Immunoexpression in Glioma |
| title_sort | idh1 r132h immunoexpression in glioma |
| topic | IDH1 Immunohistochemistry Glioma |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/150 |
| work_keys_str_mv | AT nyansaeedomer idh1r132himmunoexpressioninglioma AT jalalalijalal idh1r132himmunoexpressioninglioma AT avatahirismael idh1r132himmunoexpressioninglioma |