Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core

Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core

We previously found that host–guest interactions can drive gingerols (Gs) and cyclodextrins (CDs) together to form inclusion complexes (G/CD), which can further construct amphiphilic microcrystals and resultant Pickering emulsions through self-assembly. In this follow-up study, we explored the detai...

Full description

Saved in:
Bibliographic Details
Main Authors: Xingran Kou, Dongdong Su, Jingzhi Zhang, Fei Pan, Jiamin Zhu, Qingran Meng, Qinfei Ke
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Foods
Subjects:
β-cyclodextrin
6-gingerol
self-assembly
Pickering emulsion
Online Access:https://www.mdpi.com/2304-8158/14/6/1066
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We previously found that host–guest interactions can drive gingerols (Gs) and cyclodextrins (CDs) together to form inclusion complexes (G/CD), which can further construct amphiphilic microcrystals and resultant Pickering emulsions through self-assembly. In this follow-up study, we explored the detailed formation processes and mechanisms of the 6-G/β-CD inclusion complex and the resultant Pickering emulsion. The influence of the 6-G/β-CD molar ratio on the structure, morphology, and loading capacity of the inclusion complex and resultant Pickering emulsion were investigated. The results show that the cyclodextrin-based Pickering emulsion can load 6-G in two places; one place is the cyclodextrin cavity, whose loading capacity is up to 9.28%, while the other one is the Pickering core, with its highest loading capacity at 32.31% when the 6-G/β-CD molar ratio is 5:1. In the above case, the 6-G/β-CD inclusion complex was found to form a unit cell with a 1:2 molar ratio and then self-assemble into amphiphilic microcrystals through cage-type arrangement structures at the oil–water interface, mainly driven by van der Waals forces and hydrogen bonds. This study is helpful in the design and preparation of CD-based high-loading carriers for bioactive compound delivery.
ISSN:2304-8158

Similar Items