Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation
There are many causes of osteoporosis, and one of them is deficiency in vitamin D resulting from vitamin D receptor polymorphism. This polymorphism makes the bones and tissues that contain vitamin D receptors resistant to vitamin D and not getting enough concentrations. The aim of this study is to...
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College of Pharmacy University of Baghdad
2025-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3084 |
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| author | Noor Mohammed Abdulrahman Shatha Hussein Ali |
| author_facet | Noor Mohammed Abdulrahman Shatha Hussein Ali |
| author_sort | Noor Mohammed Abdulrahman |
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There are many causes of osteoporosis, and one of them is deficiency in vitamin D resulting from vitamin D receptor polymorphism. This polymorphism makes the bones and tissues that contain vitamin D receptors resistant to vitamin D and not getting enough concentrations. The aim of this study is to find the correlation between vitamin D receptor Taq1 (rs731236) gene polymorphism and bone turnover markers (procollagen-I and deoxypyridinoline) in postmenopausal osteoporotic women after taking a certain dose of vitamin D. Forty postmenopausal women were included who were diagnosed with osteoporosis according to WHO guidelines by taking bone mineral density measurements by DXA-scan. The participating patients received a vitamin D dose (50000 IU/week) for a duration of two months; this is the patients’ group. The control group consisted of thirty postmenopausal women without osteoporosis. The patients were divided into two groups based on their responses to vitamin D doses. Regarding allele frequency, GA has a higher percent (57.5%, 46.6%) in the patients’ group and control group, respectively. There is a non-significant difference (p = 0.11) between responders, non-responders, or the control group regarding GA genotype frequency. Bone turnover markers (procollagen-I and deoxypyridinoline) show no significant difference between groups. (p=0.22, p=0.89) at the pre-treatment level, respectively. There is a significant difference (p = 0.01) in vitamin D levels between the patients’ group and the control group. Vitamin D receptor Taq 1 (rs731236) gene polymorphism can assist in osteoporotic development through its effect on vitamin D level and, as a sequence, on bone turnover markers, making female osteoporotic patients.
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| format | Article |
| id | doaj-art-c565a1a014c248ecb2271ff0c66edbf0 |
| institution | Kabale University |
| issn | 1683-3597 2521-3512 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | College of Pharmacy University of Baghdad |
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| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj-art-c565a1a014c248ecb2271ff0c66edbf02025-08-20T03:30:34ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122025-06-0134210.31351/vol34iss2pp175-183Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D SupplementationNoor Mohammed Abdulrahman0Shatha Hussein Ali1Clinical Pharmacy Department, College of Pharmacy, University of Basrah, Basrah, IraqClinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq There are many causes of osteoporosis, and one of them is deficiency in vitamin D resulting from vitamin D receptor polymorphism. This polymorphism makes the bones and tissues that contain vitamin D receptors resistant to vitamin D and not getting enough concentrations. The aim of this study is to find the correlation between vitamin D receptor Taq1 (rs731236) gene polymorphism and bone turnover markers (procollagen-I and deoxypyridinoline) in postmenopausal osteoporotic women after taking a certain dose of vitamin D. Forty postmenopausal women were included who were diagnosed with osteoporosis according to WHO guidelines by taking bone mineral density measurements by DXA-scan. The participating patients received a vitamin D dose (50000 IU/week) for a duration of two months; this is the patients’ group. The control group consisted of thirty postmenopausal women without osteoporosis. The patients were divided into two groups based on their responses to vitamin D doses. Regarding allele frequency, GA has a higher percent (57.5%, 46.6%) in the patients’ group and control group, respectively. There is a non-significant difference (p = 0.11) between responders, non-responders, or the control group regarding GA genotype frequency. Bone turnover markers (procollagen-I and deoxypyridinoline) show no significant difference between groups. (p=0.22, p=0.89) at the pre-treatment level, respectively. There is a significant difference (p = 0.01) in vitamin D levels between the patients’ group and the control group. Vitamin D receptor Taq 1 (rs731236) gene polymorphism can assist in osteoporotic development through its effect on vitamin D level and, as a sequence, on bone turnover markers, making female osteoporotic patients. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3084Bone turnover markersDeoxypyridinolineOsteoporosisProcollagen-IVitamin D receptor |
| spellingShingle | Noor Mohammed Abdulrahman Shatha Hussein Ali Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation Iraqi Journal of Pharmaceutical Sciences Bone turnover markers Deoxypyridinoline Osteoporosis Procollagen-I Vitamin D receptor |
| title | Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation |
| title_full | Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation |
| title_fullStr | Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation |
| title_full_unstemmed | Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation |
| title_short | Polymorphism of Vitamin D Receptor Gene Taq1 (rs731236) and its Effect on Bone Turnover Markers in Iraqi Postmenopausal Osteoporotic Women After Vitamin D Supplementation |
| title_sort | polymorphism of vitamin d receptor gene taq1 rs731236 and its effect on bone turnover markers in iraqi postmenopausal osteoporotic women after vitamin d supplementation |
| topic | Bone turnover markers Deoxypyridinoline Osteoporosis Procollagen-I Vitamin D receptor |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3084 |
| work_keys_str_mv | AT noormohammedabdulrahman polymorphismofvitamindreceptorgenetaq1rs731236anditseffectonboneturnovermarkersiniraqipostmenopausalosteoporoticwomenaftervitamindsupplementation AT shathahusseinali polymorphismofvitamindreceptorgenetaq1rs731236anditseffectonboneturnovermarkersiniraqipostmenopausalosteoporoticwomenaftervitamindsupplementation |