Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS

Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS

BackgroundA stable and reproducible experimental bacterial pneumonia model postintracerebral hemorrhage (ICH) is necessary to help investigating the pathogenesis and novel treatments of Stroke-associated pneumonia (SAP).AimTo establish a Gram-negative bacterial pneumonia-complicating ICH rat model a...

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Bibliographic Details
Main Authors: Ruihua Wang, Changlian Gan, Rui Mao, Yang Chen, Ru Yan, Geng Li, Tianqin Xiong, Jianwen Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
intracerebral hemorrhage
stroke-associated pneumonia
Klebsiella pneumoniae
lipopolysaccharide
16S rRNA sequencing and untargeted metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1477902/full
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