Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trialResearch in context

Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trialResearch in context

Summary: Background: Glucocorticoids (GC) are potent entrainers of the circadian clock. However, their effects on biological rhythms in chronic human exposure have yet to be studied. Endogenous hypercortisolism (Cushing's Syndrome, CS) is a rare condition in which circadian disruption is susta...

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Main Authors: Valeria Hasenmajer, Emilia Sbardella, Francesca Sciarra, Chiara Simeoli, Claudia Pivonello, Filippo Ceccato, Riccardo Pofi, Marianna Minnetti, Flavio Rizzo, Davide Ferrari, Ilaria Bonaventura, Federica Barbagallo, Elisa Giannetta, Danilo Alunni Fegatelli, Simone Conia, Roberto Navigli, Giorgio Arnaldi, Carla Scaroni, Rosario Pivonello, Daniele Gianfrilli, Mary Anna Venneri, Andrea M. Isidori
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EBioMedicine
Subjects:
Cushing's syndrome
Hypercortisolism
Circadian rhythm
Glucocorticoids
Immune system
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004985
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