Dosage suppressors of gpn2ts mutants and functional insights into the role of Gpn2 in budding yeast.

Dosage suppressors of gpn2ts mutants and functional insights into the role of Gpn2 in budding yeast.

Gpn2 is a highly conserved protein essential for the assembly of RNA polymerase II (RNAPII) in eukaryotic cells. Mutations in Gpn2, specifically Phe105Tyr and Leu164Pro, confer temperature sensitivity and significantly impair RNAPII assembly. Despite its crucial role, the complete range of Gpn2 func...

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Bibliographic Details
Main Authors: Le Wang, Pan Li, Pei Zeng, Debao Xie, Mengdi Gao, Lujie Ma, Aamir Sohail, Fanli Zeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0313597
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