Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review
Introduction Erectile dysfunction (ED) is the most common male sexual disorder that severely impacts the sexual performance and quality of life of men. As the main subtype of ED, psychogenic ED (pED) has been demonstrated to be a genitourinary disease and also associated with alterations in both bra...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/8/e030061.full |
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| author | Tao Yin Zhengjie Li Jing Xiong Lei Lan Ruirui Sun Feiqiang Ren Peihai Zhang |
| author_facet | Tao Yin Zhengjie Li Jing Xiong Lei Lan Ruirui Sun Feiqiang Ren Peihai Zhang |
| author_sort | Tao Yin |
| collection | DOAJ |
| description | Introduction Erectile dysfunction (ED) is the most common male sexual disorder that severely impacts the sexual performance and quality of life of men. As the main subtype of ED, psychogenic ED (pED) has been demonstrated to be a genitourinary disease and also associated with alterations in both brain structure and function. However, the scattered neuroimaging evidence from individual studies has not yet been integrated, and the central pathological alterations associated with pED remain unclear. The objective of this systematic review is to integrate and assess the evidence of the impact of pED on brain structure and function.Methods and analysis Five databases (PubMed, EMBASE, Web of Science, China Biology Medicine Database and China National Knowledge Infrastructure (CNKI)) will be systematically searched from inception to 1 October 2019 (the anticipated completion date of this review), with language restricted to English and Chinese. Studies focusing on the structural or functional alterations in patients with pED will be retrieved. The study selection process will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and quality assessment will be conducted with a customised checklist. After data extraction, a qualitative review will be performed to synthesise the structural and functional brain alterations as well as the correlations between the altered cerebral structures and functions and the clinical characteristics of patients with pED. If the collected data make it feasible, an activation likelihood estimation meta-analysis will also be launched.Ethics and dissemination Ethical approval is not required as primary data will not be collected. This review will be published in a peer-reviewed journal and presented at conferences.PROSPERO registration number CRD42019117206. |
| format | Article |
| id | doaj-art-c5525f81832f47cabc652a009f38b062 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-c5525f81832f47cabc652a009f38b0622025-08-20T01:53:36ZengBMJ Publishing GroupBMJ Open2044-60552019-08-019810.1136/bmjopen-2019-030061Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic reviewTao Yin0Zhengjie Li1Jing Xiong2Lei Lan3Ruirui Sun4Feiqiang Ren5Peihai Zhang6National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University, Changsha, ChinaSchool of Automation, Qingdao University, Qingdao, Shandong Province, People`s Republic of ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaClinical Medicine School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaUrology and Andrology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaIntroduction Erectile dysfunction (ED) is the most common male sexual disorder that severely impacts the sexual performance and quality of life of men. As the main subtype of ED, psychogenic ED (pED) has been demonstrated to be a genitourinary disease and also associated with alterations in both brain structure and function. However, the scattered neuroimaging evidence from individual studies has not yet been integrated, and the central pathological alterations associated with pED remain unclear. The objective of this systematic review is to integrate and assess the evidence of the impact of pED on brain structure and function.Methods and analysis Five databases (PubMed, EMBASE, Web of Science, China Biology Medicine Database and China National Knowledge Infrastructure (CNKI)) will be systematically searched from inception to 1 October 2019 (the anticipated completion date of this review), with language restricted to English and Chinese. Studies focusing on the structural or functional alterations in patients with pED will be retrieved. The study selection process will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and quality assessment will be conducted with a customised checklist. After data extraction, a qualitative review will be performed to synthesise the structural and functional brain alterations as well as the correlations between the altered cerebral structures and functions and the clinical characteristics of patients with pED. If the collected data make it feasible, an activation likelihood estimation meta-analysis will also be launched.Ethics and dissemination Ethical approval is not required as primary data will not be collected. This review will be published in a peer-reviewed journal and presented at conferences.PROSPERO registration number CRD42019117206.https://bmjopen.bmj.com/content/9/8/e030061.full |
| spellingShingle | Tao Yin Zhengjie Li Jing Xiong Lei Lan Ruirui Sun Feiqiang Ren Peihai Zhang Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review BMJ Open |
| title | Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review |
| title_full | Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review |
| title_fullStr | Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review |
| title_full_unstemmed | Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review |
| title_short | Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review |
| title_sort | neuroimaging biomarkers of psychogenic erectile dysfunction protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/9/8/e030061.full |
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