Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial

Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial

Abstract Purpose Total knee arthroplasty (TKA) has significant perioperative blood loss and a high transfusion rate. Tranexamic acid (TXA) has widely recognized hemostatic efficacy in TKA. Hemocoagulase Agkistrodon (HCA) enhances coagulation by hydrolyzing fibrinogen into fibrin, complements the hem...

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Bibliographic Details
Main Authors: Yucan Ju, Huansheng Liu, Wenyu Jiang, Qiang Huang, Zongke Zhou, Fuxing Pei
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Total knee arthroplasty
Hemocoagulase Agkistrodon
Blood loss
Tranexamic acid
Online Access:https://doi.org/10.1186/s13018-025-05867-0
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