Three-dimensional conformal therapy vs. intensity modulated radiation therapy in GBM: survival, dosimetry, and side effects a systematic review and meta-analysis

Three-dimensional conformal therapy vs. intensity modulated radiation therapy in GBM: survival, dosimetry, and side effects a systematic review and meta-analysis

BackgroundGlioblastoma multiforme (GBM) is an aggressive brain tumor with a poor prognosis, often managed with radiotherapy. Two primary modalities, three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT), differ in their precision and impact on survival, side e...

Full description

Saved in:

Bibliographic Details
Main Authors:	Omar Freihat, David Sipos, Reham Kotb, Maria Aamir, Dóra Solymosi, Kristóf Gál, Simon Mihály, Arpad Kovacs
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Physics
Subjects:	glioblastoma multiforme (GBM) intensity-modulated radiotherapy (IMRT) three-dimensional conformal radiotherapy (3D-CRT) overall survival (OS) organs at risk glioblastoma multiforme (GBM) dosimetry
Online Access:	https://www.frontiersin.org/articles/10.3389/fphy.2025.1632620/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Severe Unilateral Alopecia in a Long-Term Surviving Male Adolescent Glioblastoma Multiforme Patient
by: Xiong L, et al.
Published: (2025-06-01)

Delta-radiomics Entropy Based on Tumor Heterogeneity Concept – Response Predictor to Irradiation for Unresectable/recurrent Glioblastoma
by: Camil Ciprian MIRESTEAN, et al.
Published: (2022-12-01)

Interplay Between Diabetes, Obesity and Glioblastoma Multiforme, and the Role of Nanotechnology in Its Treatment
by: Sourav De, et al.
Published: (2025-02-01)

Nanomedicine-Enhanced Radiotherapy for Glioblastoma: Advances in Targeted Therapy and Adaptive Treatment Strategies
by: Kamila Rawojć, et al.
Published: (2025-04-01)

Glioblastoma multiforme: A rare case of GBM
by: Albert Paul Varghese, et al.
Published: (2024-10-01)

The Role of Insulin Receptor Substrate 4 (IRS4) Protein in the Radiotherapy Response of Glioblastoma Multiforme (GBM) Cells
by: Gökhan Görgişen, et al.
Published: (2024-10-01)

Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)
by: Madeline K. Brown, et al.
Published: (2025-07-01)

Metástases intrarraquidianas de glioblastoma multiforme supratentorial da infância: relato de caso Spinal cord metastatic glioblastoma multiforme of childhood: case report
by: Patricia Imperatriz Porto Rondinelli, et al.
Published: (2002-09-01)

Immunological Insights into Photodynamic Therapy of Glioblastoma Multiforme
by: Paweł Woźnicki, et al.
Published: (2025-07-01)

A Rare Case of Drop Metastasis along Lumbar Column of Glioblastoma Multiforme
by: Rafaela Jucá Lindner, et al.
Published: (2024-12-01)

Pediatric glioblastoma multiforme: A single-institution experience
by: Mansour Ansari, et al.
Published: (2012-01-01)

Correlação clínico-topográfica em glioblastomas multiformes nas síndromes motoras: significados fisiopatológicos Clinical topographic findings in glioblastoma multiforme and the relation with motor impairment
by: Rita de Cássia G. Lucena, et al.
Published: (2006-06-01)

Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study
by: Andreas Kiryttopoulos, et al.
Published: (2025-02-01)

Corrigendum: Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study
by: Andreas Kiryttopoulos, et al.
Published: (2025-05-01)

Potential of Curcumin and Its Analogs in Glioblastoma Therapy
by: Agnieszka Nowacka, et al.
Published: (2025-03-01)

The Adverse Effects and Use of Bevacizumab in Patients with Glioblastoma: A Systematic Review and Meta-Analysis
by: Alejandro Bruna-Mejías, et al.
Published: (2025-05-01)

Modern Radiotherapy for Head and Neck Cancers: Benefits and Pitfalls - a Literature Review
by: CAMIL CIPRIAN MIRESTEAN, et al.
Published: (2019-09-01)

Homologous tumor cell exosome-based drug delivery system co-delivering temozolomide and resveratrol for orthotopic glioblastoma therapy
by: Xuemei Wang, et al.
Published: (2025-12-01)

The therapeutic potential of curcumin for the treatment of glioblastoma multiforme
by: T. I. Kushnir, et al.
Published: (2020-03-01)

Estudo através da ressonância magnética de 67 casos de glioblastoma multiforme e a ocorrência de metástases
by: Nelson Fortes Ferreira, et al.
Published: (2004-09-01)

A multi-omics target study for glioblastoma multiforme (GBM) based on Mendelian randomization analysis
by: Hao Sun, et al.
Published: (2025-06-01)

Ferroptosis determinants - potential therapeutic targets glioblastoma stem cells
by: V. E. Shevchenko, et al.
Published: (2022-10-01)

Exploratory Study on Nanoparticle Co-Delivery of Temozolomide and Ligustilide for Enhanced Brain Tumor Therapy
by: Gang Ke, et al.
Published: (2025-02-01)

Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma
by: Yiran Guo, et al.
Published: (2025-04-01)

Increased intracranial pressure in a case of spinal cervical glioblastoma multiforme: analysis of these two rare conditions
by: C.M. de Castro-Costa, et al.
Published: (1994-03-01)

Glioblastoma Multiforme in the Cerebellopontine Angle in a Pediatric Patient
by: Ivethe Pregúntegui-Loayza, et al.
Published: (2021-08-01)

A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches
by: Meijun Liu, et al.
Published: (2025-06-01)

Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies
by: Ewelina Musielak, et al.
Published: (2025-01-01)

The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies
by: Jolie Bou-Gharios, et al.
Published: (2024-11-01)

Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy
by: Smita Dey, et al.
Published: (2025-07-01)

Double Primary Brain Tumors of Different Histology in the Same Patient
by: Mithilesh Kumar Pandey, et al.
Published: (2015-12-01)

Comparative cytotoxicity of perphenazine on different human glioblastoma cells
by: Michał Otręba, et al.
Published: (2025-06-01)

Taurochenodeoxycholic acid suppresses the progression of glioblastoma via HMGCS1/HMGCR/GPX4 signaling pathway in vitro and in vivo
by: Xiumin Xue, et al.
Published: (2025-04-01)

Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment
by: Mieszko Lachota, et al.
Published: (2025-08-01)

Potential Risk of Cognitive Impairment Due to Irradiation of Neural Structures in Locally Advanced Nasopharyngeal Cancer Treated by Curative Radiotherapy
by: Camil Ciprian Mireștean, et al.
Published: (2025-04-01)

Cerebellar glioblastoma multiforme in an adult
by: João Paulo Mattos, et al.
Published: (2006-03-01)

CRP/albumin ratio and WBC values correlate with Ki-67 and survival in glioblastoma multiforme
by: Güven Gürsoy
Published: (2025-06-01)

Systematic Review of Pre-Clinical Systems Using Artificial Microenvironments and Anti-Migratory Drugs to Control Migration of Glioblastoma Cells
by: Hana Selvi, et al.
Published: (2025-01-01)

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme
by: Jun Yang, et al.
Published: (2025-07-01)

The effect of hypoxia on the secretome of human glioblastoma multiforme cells
by: T. I. Kushnir, et al.
Published: (2021-05-01)