Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney
In addition to a wide range of adverse effects on human health, toxic metals such as cadmium (Cd) can promote kidney damage. In this study, we proposed the toxicological properties of these metals which are partly related to lipid peroxidation and chlorinative stress. Thus our study aimed to measure...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2015-06-01
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| Series: | Journal of Experimental Life Science |
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| Online Access: | https://jels.ub.ac.id/index.php/jels/article/view/154 |
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| author | Eko Suhartono Triawanti Triawanti Amin Setyo Leksono |
| author_facet | Eko Suhartono Triawanti Triawanti Amin Setyo Leksono |
| author_sort | Eko Suhartono |
| collection | DOAJ |
| description | In addition to a wide range of adverse effects on human health, toxic metals such as cadmium (Cd) can promote kidney damage. In this study, we proposed the toxicological properties of these metals which are partly related to lipid peroxidation and chlorinative stress. Thus our study aimed to measure the lipid peroxidation and chlorinative stress in kidney of rats exposed to Cd. The study was performed on 32 male rats (Rattus novergicus) weighing 300±10 grams with normal activity. Rats were acclimatized for a week before the treatment. The animals were divided into two major groups with one group for control (K0) and the other groups were exposed to 3 mg/L CdSO4 through the drinking water. The animals in each groups were divided again into two small groups with different time of exposure. The time of exposure are subacute (six weeks) and subchronic (eight weeks). After the exposure the kidney from all treated animals showed the significant increase of MDA and AOPP levels. In conclusion, subacute and subchronic exposure of Cd caused the kidney damage through lipid peroxidation and chlorinative stress, as shown by increasing of MDA and AOPP levels. |
| format | Article |
| id | doaj-art-c54849df7fa44cf3b7f189af1e27df44 |
| institution | Kabale University |
| issn | 2087-2852 2338-1655 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Experimental Life Science |
| spelling | doaj-art-c54849df7fa44cf3b7f189af1e27df442025-08-20T03:47:32ZengUniversity of BrawijayaJournal of Experimental Life Science2087-28522338-16552015-06-015115https://doi.org/10.21776/ub.jels.2015.005.01.01Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat KidneyEko Suhartono0Triawanti Triawanti1Amin Setyo Leksono2Universitas Brawijaya, Malang, IndonesiaUniversitas Lambung Mangkurat, Banjarmasin, IndonesiaUniversitas Brawijaya, Malang, IndonesiaIn addition to a wide range of adverse effects on human health, toxic metals such as cadmium (Cd) can promote kidney damage. In this study, we proposed the toxicological properties of these metals which are partly related to lipid peroxidation and chlorinative stress. Thus our study aimed to measure the lipid peroxidation and chlorinative stress in kidney of rats exposed to Cd. The study was performed on 32 male rats (Rattus novergicus) weighing 300±10 grams with normal activity. Rats were acclimatized for a week before the treatment. The animals were divided into two major groups with one group for control (K0) and the other groups were exposed to 3 mg/L CdSO4 through the drinking water. The animals in each groups were divided again into two small groups with different time of exposure. The time of exposure are subacute (six weeks) and subchronic (eight weeks). After the exposure the kidney from all treated animals showed the significant increase of MDA and AOPP levels. In conclusion, subacute and subchronic exposure of Cd caused the kidney damage through lipid peroxidation and chlorinative stress, as shown by increasing of MDA and AOPP levels.https://jels.ub.ac.id/index.php/jels/article/view/154aoppcadmiumchlorinative stresslipid peroxidationmda |
| spellingShingle | Eko Suhartono Triawanti Triawanti Amin Setyo Leksono Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney Journal of Experimental Life Science aopp cadmium chlorinative stress lipid peroxidation mda |
| title | Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney |
| title_full | Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney |
| title_fullStr | Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney |
| title_full_unstemmed | Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney |
| title_short | Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney |
| title_sort | effects of cadmium exposure on lipid peroxidation and chlorinative stress of rat kidney |
| topic | aopp cadmium chlorinative stress lipid peroxidation mda |
| url | https://jels.ub.ac.id/index.php/jels/article/view/154 |
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