Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification
Bladder cancer (BC) is the most common neoplasm of the urinary system and ranks tenth in global cancer incidence. Due to its high recurrence rate and the need for continuous monitoring, it is the cancer with the highest cost per patient. Cystoscopy is the traditional method for its detection and sur...
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MDPI AG
2024-11-01
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| author | Manuel Alejandro Rico-Méndez María de la Luz Ayala-Madrigal Anahí González-Mercado Melva Gutiérrez-Angulo Jorge Adrián Ramírez de Arellano Sánchez Saul Armando Beltrán-Ontiveros Betsabe Contreras-Haro Itzae Adonai Gutiérrez-Hurtado José Miguel Moreno-Ortiz |
| author_facet | Manuel Alejandro Rico-Méndez María de la Luz Ayala-Madrigal Anahí González-Mercado Melva Gutiérrez-Angulo Jorge Adrián Ramírez de Arellano Sánchez Saul Armando Beltrán-Ontiveros Betsabe Contreras-Haro Itzae Adonai Gutiérrez-Hurtado José Miguel Moreno-Ortiz |
| author_sort | Manuel Alejandro Rico-Méndez |
| collection | DOAJ |
| description | Bladder cancer (BC) is the most common neoplasm of the urinary system and ranks tenth in global cancer incidence. Due to its high recurrence rate and the need for continuous monitoring, it is the cancer with the highest cost per patient. Cystoscopy is the traditional method for its detection and surveillance; however, this is an invasive technique, while non-invasive methods, such as cytology, have a limited sensitivity. For this reason, new non-invasive strategies have emerged, analyzing useful markers for BC detection from urine samples. The identification of tumor markers is essential for early cancer detection and treatment. Urine analysis offers a non-invasive method to identify these markers. Microsatellite instability (MSI) has been proposed as a promising marker for tumor cell detection and guided targeted therapies. Therefore, this review aims to explore the evidence supporting the identification of MSI in exfoliated bladder tumor cells (EBTCs) in the urine, emphasizing its potential as a non-invasive and clinically effective alternative for tumor identification. Furthermore, establishing clinical guidelines is crucial for standardizing its application in oncological screening and validating its clinical utility. |
| format | Article |
| id | doaj-art-c545dd5de9bd4d27bd19036c5f208c0b |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-c545dd5de9bd4d27bd19036c5f208c0b2025-08-20T02:53:37ZengMDPI AGBiomedicines2227-90592024-11-011212272610.3390/biomedicines12122726Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer IdentificationManuel Alejandro Rico-Méndez0María de la Luz Ayala-Madrigal1Anahí González-Mercado2Melva Gutiérrez-Angulo3Jorge Adrián Ramírez de Arellano Sánchez4Saul Armando Beltrán-Ontiveros5Betsabe Contreras-Haro6Itzae Adonai Gutiérrez-Hurtado7José Miguel Moreno-Ortiz8Doctorado en Genética Humana, Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoDoctorado en Genética Humana, Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoDoctorado en Genética Humana, Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoDepartamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47600, Jalisco, MexicoInstituto de Investigación en Ciencias Biomédicas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoCentrode Investigación y Docencia en Ciencias de la Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, MexicoUnidad de Investigación Biomédica 02, Unidades Médicas de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44329, Jalisco, MexicoDepartamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoDoctorado en Genética Humana, Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, MexicoBladder cancer (BC) is the most common neoplasm of the urinary system and ranks tenth in global cancer incidence. Due to its high recurrence rate and the need for continuous monitoring, it is the cancer with the highest cost per patient. Cystoscopy is the traditional method for its detection and surveillance; however, this is an invasive technique, while non-invasive methods, such as cytology, have a limited sensitivity. For this reason, new non-invasive strategies have emerged, analyzing useful markers for BC detection from urine samples. The identification of tumor markers is essential for early cancer detection and treatment. Urine analysis offers a non-invasive method to identify these markers. Microsatellite instability (MSI) has been proposed as a promising marker for tumor cell detection and guided targeted therapies. Therefore, this review aims to explore the evidence supporting the identification of MSI in exfoliated bladder tumor cells (EBTCs) in the urine, emphasizing its potential as a non-invasive and clinically effective alternative for tumor identification. Furthermore, establishing clinical guidelines is crucial for standardizing its application in oncological screening and validating its clinical utility.https://www.mdpi.com/2227-9059/12/12/2726bladder cancermicrosatellite instabilityexfoliated bladder tumor cellsmarkermicrosatellite instability analysisurine |
| spellingShingle | Manuel Alejandro Rico-Méndez María de la Luz Ayala-Madrigal Anahí González-Mercado Melva Gutiérrez-Angulo Jorge Adrián Ramírez de Arellano Sánchez Saul Armando Beltrán-Ontiveros Betsabe Contreras-Haro Itzae Adonai Gutiérrez-Hurtado José Miguel Moreno-Ortiz Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification Biomedicines bladder cancer microsatellite instability exfoliated bladder tumor cells marker microsatellite instability analysis urine |
| title | Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification |
| title_full | Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification |
| title_fullStr | Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification |
| title_full_unstemmed | Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification |
| title_short | Microsatellite Instability in Urine: Breakthrough Method for Bladder Cancer Identification |
| title_sort | microsatellite instability in urine breakthrough method for bladder cancer identification |
| topic | bladder cancer microsatellite instability exfoliated bladder tumor cells marker microsatellite instability analysis urine |
| url | https://www.mdpi.com/2227-9059/12/12/2726 |
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