Microvascular flow imaging of fibroids: A prospective pilot study
Abstract Introduction Imaging fibroid vascularity may predict fibroid growth and aid to determine most appropriate therapy. Microvascular (MV) flow imaging is relatively new and is able to detect slow flow in small vessels. Data on feasibility, reproducibility, and reliability of MV‐flow imaging in...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14914 |
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| author | Marissa Frijlingh Barbara Stoelinga Robert A. deLeeuw Wouter J. K. Hehenkamp Jos W. R. Twisk Thierry van denBosch Lynda J. M. Juffermans Judith A. F. Huirne |
| author_facet | Marissa Frijlingh Barbara Stoelinga Robert A. deLeeuw Wouter J. K. Hehenkamp Jos W. R. Twisk Thierry van denBosch Lynda J. M. Juffermans Judith A. F. Huirne |
| author_sort | Marissa Frijlingh |
| collection | DOAJ |
| description | Abstract Introduction Imaging fibroid vascularity may predict fibroid growth and aid to determine most appropriate therapy. Microvascular (MV) flow imaging is relatively new and is able to detect slow flow in small vessels. Data on feasibility, reproducibility, and reliability of MV‐flow imaging in fibroids is lacking. The purpose of our study was to determine the reproducibility of MV‐flow imaging and to explore this technique for clinical practice for assessing blood flow in fibroids. Material and Methods Thirty patients with one or multiple fibroids (diameter 1.5–12.0 cm) were prospectively included. Transvaginal ultrasound scanning was performed in B‐mode, 2D MV‐Flow™, 2D and 3D power Doppler mode (HERA W10, Samsung) by two experienced gynecologists at a tertiary care clinic from February to December 2021. The primary outcome was intra‐ and interobserver agreement of the vascular index (VI) and color score (CS). The following parameters: ‘2D MV‐flow VI’, ‘3DPD VI’, ‘2D MV‐flow CS’ and ‘2DPD CS’ were measured offline in the center, pseudocapsule, and entire fibroid. Secondary offline outcomes for exploring 2D MV‐flow for clinical practice, included (1) ability to discern vascular structures, (2) assessing the degree of vascularity via CS and calculating a VI, and (3) determining penetration depth of the ultrasound signal in both power Doppler and MV‐flow imaging. Results All scans of the 30 included patients were of sufficient quality to analyze. Inter‐ and intra‐observer correlations of all studied parameters were good to excellent, both for 2D MV‐flow and 2D power Doppler (intercorrelation coefficient 0.992–0.996). Using 2D MV‐flow different vascular structures were visible in detail, in contrary to using 2D and 3D power Doppler. In significantly more fibroids central flow could be visualized using 2D MV‐flow (63%) than with 2D power Doppler (13%, p = 0.001). Finally, penetration of the ultrasound signal was deeper using 2D MV‐flow (3.92 cm) than with 2D power Doppler (2.95 cm, p = 0.001). Conclusions Using 2D MV‐flow imaging for determining vascularity is highly reproducible. It has potential added value for clinical practice as it depicts detailed vascular structures and the degree of vascularity, especially in the center of the fibroid. |
| format | Article |
| id | doaj-art-c545a45898e044da9ee8d7dbbf2f1632 |
| institution | DOAJ |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-c545a45898e044da9ee8d7dbbf2f16322025-08-20T03:22:16ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122024-11-01103112193220210.1111/aogs.14914Microvascular flow imaging of fibroids: A prospective pilot studyMarissa Frijlingh0Barbara Stoelinga1Robert A. deLeeuw2Wouter J. K. Hehenkamp3Jos W. R. Twisk4Thierry van denBosch5Lynda J. M. Juffermans6Judith A. F. Huirne7Department of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Epidemiology and Biostatistics Amsterdam UMC, location VUmc Amsterdam The NetherlandsDepartment of Obstetrics and Gynecology University Hospital KU Leuven Leuven BelgiumDepartment of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Obstetrics and Gynecology Amsterdam UMC, location AMC Amsterdam The NetherlandsAbstract Introduction Imaging fibroid vascularity may predict fibroid growth and aid to determine most appropriate therapy. Microvascular (MV) flow imaging is relatively new and is able to detect slow flow in small vessels. Data on feasibility, reproducibility, and reliability of MV‐flow imaging in fibroids is lacking. The purpose of our study was to determine the reproducibility of MV‐flow imaging and to explore this technique for clinical practice for assessing blood flow in fibroids. Material and Methods Thirty patients with one or multiple fibroids (diameter 1.5–12.0 cm) were prospectively included. Transvaginal ultrasound scanning was performed in B‐mode, 2D MV‐Flow™, 2D and 3D power Doppler mode (HERA W10, Samsung) by two experienced gynecologists at a tertiary care clinic from February to December 2021. The primary outcome was intra‐ and interobserver agreement of the vascular index (VI) and color score (CS). The following parameters: ‘2D MV‐flow VI’, ‘3DPD VI’, ‘2D MV‐flow CS’ and ‘2DPD CS’ were measured offline in the center, pseudocapsule, and entire fibroid. Secondary offline outcomes for exploring 2D MV‐flow for clinical practice, included (1) ability to discern vascular structures, (2) assessing the degree of vascularity via CS and calculating a VI, and (3) determining penetration depth of the ultrasound signal in both power Doppler and MV‐flow imaging. Results All scans of the 30 included patients were of sufficient quality to analyze. Inter‐ and intra‐observer correlations of all studied parameters were good to excellent, both for 2D MV‐flow and 2D power Doppler (intercorrelation coefficient 0.992–0.996). Using 2D MV‐flow different vascular structures were visible in detail, in contrary to using 2D and 3D power Doppler. In significantly more fibroids central flow could be visualized using 2D MV‐flow (63%) than with 2D power Doppler (13%, p = 0.001). Finally, penetration of the ultrasound signal was deeper using 2D MV‐flow (3.92 cm) than with 2D power Doppler (2.95 cm, p = 0.001). Conclusions Using 2D MV‐flow imaging for determining vascularity is highly reproducible. It has potential added value for clinical practice as it depicts detailed vascular structures and the degree of vascularity, especially in the center of the fibroid.https://doi.org/10.1111/aogs.14914Dopplerfibroidsmicrovascular flowsonographyultrasoundvascularity |
| spellingShingle | Marissa Frijlingh Barbara Stoelinga Robert A. deLeeuw Wouter J. K. Hehenkamp Jos W. R. Twisk Thierry van denBosch Lynda J. M. Juffermans Judith A. F. Huirne Microvascular flow imaging of fibroids: A prospective pilot study Acta Obstetricia et Gynecologica Scandinavica Doppler fibroids microvascular flow sonography ultrasound vascularity |
| title | Microvascular flow imaging of fibroids: A prospective pilot study |
| title_full | Microvascular flow imaging of fibroids: A prospective pilot study |
| title_fullStr | Microvascular flow imaging of fibroids: A prospective pilot study |
| title_full_unstemmed | Microvascular flow imaging of fibroids: A prospective pilot study |
| title_short | Microvascular flow imaging of fibroids: A prospective pilot study |
| title_sort | microvascular flow imaging of fibroids a prospective pilot study |
| topic | Doppler fibroids microvascular flow sonography ultrasound vascularity |
| url | https://doi.org/10.1111/aogs.14914 |
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