Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications
Abstract This report describes opioid‐induced neurotoxicity (OIN) in two dogs with hydrocephalus undergoing the investigation of recurrent seizures; in both dogs, myoclonus occurred following premedication with butorphanol and remifentanil and resolved following the administration of midazolam. Thor...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.70277 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850139824832380928 |
|---|---|
| author | Changhoon Nam Inhyung Lee Won‐gyun Son |
| author_facet | Changhoon Nam Inhyung Lee Won‐gyun Son |
| author_sort | Changhoon Nam |
| collection | DOAJ |
| description | Abstract This report describes opioid‐induced neurotoxicity (OIN) in two dogs with hydrocephalus undergoing the investigation of recurrent seizures; in both dogs, myoclonus occurred following premedication with butorphanol and remifentanil and resolved following the administration of midazolam. Thorough clinical evaluation excluded underlying systemic disease and increased intracranial pressure as possible causes, and opioid‐induced modulation of gamma‐aminobutyric acid (GABA) inhibitory and dopaminergic interneurons was assumed. Benzodiazepines, like midazolam, enhanced GABA and appeared to be effective in managing these symptoms. The findings suggest that even at therapeutic doses, certain opioids can cause OIN in dogs. Caution is advised when using opioids, particularly in dogs with pre‐existing central nervous system disorders, and further research is needed to better understand dosage effects and alternative treatment options for OIN prevention. |
| format | Article |
| id | doaj-art-c542e9fd50ba48d5ac2ddf68a7cd1ac2 |
| institution | OA Journals |
| issn | 2053-1095 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj-art-c542e9fd50ba48d5ac2ddf68a7cd1ac22025-08-20T02:30:06ZengWileyVeterinary Medicine and Science2053-10952025-05-01113n/an/a10.1002/vms3.70277Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic MedicationsChanghoon Nam0Inhyung Lee1Won‐gyun Son2Department of Veterinary Clinical Sciences College of Veterinary Medicine, Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine, Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine, Seoul National University Seoul Republic of KoreaAbstract This report describes opioid‐induced neurotoxicity (OIN) in two dogs with hydrocephalus undergoing the investigation of recurrent seizures; in both dogs, myoclonus occurred following premedication with butorphanol and remifentanil and resolved following the administration of midazolam. Thorough clinical evaluation excluded underlying systemic disease and increased intracranial pressure as possible causes, and opioid‐induced modulation of gamma‐aminobutyric acid (GABA) inhibitory and dopaminergic interneurons was assumed. Benzodiazepines, like midazolam, enhanced GABA and appeared to be effective in managing these symptoms. The findings suggest that even at therapeutic doses, certain opioids can cause OIN in dogs. Caution is advised when using opioids, particularly in dogs with pre‐existing central nervous system disorders, and further research is needed to better understand dosage effects and alternative treatment options for OIN prevention.https://doi.org/10.1002/vms3.70277butorphanolcanineopioid‐induced neurotoxicitypre‐existing brain disorderremifentanil |
| spellingShingle | Changhoon Nam Inhyung Lee Won‐gyun Son Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications Veterinary Medicine and Science butorphanol canine opioid‐induced neurotoxicity pre‐existing brain disorder remifentanil |
| title | Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications |
| title_full | Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications |
| title_fullStr | Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications |
| title_full_unstemmed | Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications |
| title_short | Opioid‐Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications |
| title_sort | opioid induced myoclonus during premedication in two dogs with hydrocephalus proactively managed with antiepileptic medications |
| topic | butorphanol canine opioid‐induced neurotoxicity pre‐existing brain disorder remifentanil |
| url | https://doi.org/10.1002/vms3.70277 |
| work_keys_str_mv | AT changhoonnam opioidinducedmyoclonusduringpremedicationintwodogswithhydrocephalusproactivelymanagedwithantiepilepticmedications AT inhyunglee opioidinducedmyoclonusduringpremedicationintwodogswithhydrocephalusproactivelymanagedwithantiepilepticmedications AT wongyunson opioidinducedmyoclonusduringpremedicationintwodogswithhydrocephalusproactivelymanagedwithantiepilepticmedications |