Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis
Abstract Introduction Patients undergoing colorectal surgery for symptomatic deep endometriosis may experience postoperative impairment of gastrointestinal function. However, there is limited information on long‐term follow‐up of this surgical sequela. We aimed to analyze 5‐year postsurgical outcome...
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Wiley
2025-08-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.15142 |
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| author | Daria Pashkunova Ezgi Darici Kurt Theresa Hudelist Anna Rath Attila Bokor Gernot Hudelist |
| author_facet | Daria Pashkunova Ezgi Darici Kurt Theresa Hudelist Anna Rath Attila Bokor Gernot Hudelist |
| author_sort | Daria Pashkunova |
| collection | DOAJ |
| description | Abstract Introduction Patients undergoing colorectal surgery for symptomatic deep endometriosis may experience postoperative impairment of gastrointestinal function. However, there is limited information on long‐term follow‐up of this surgical sequela. We aimed to analyze 5‐year postsurgical outcomes of gastrointestinal function in these patients, reflected by lower anterior resection syndrome (LARS) scores and gastrointestinal quality of life index (GIQLI). Material and Methods This prospective study included patients who either underwent nerve‐vessel‐sparing segmental resection (NVSSR) or full‐thickness discoid resection (FTDR) for symptomatic colorectal deep endometriosis from April 2017 to May 2022 at two tertiary referral centers. As published previously, gastrointestinal function was evaluated by LARS and GIQLI scores pre‐ and postsurgically (postoperative visit 1) and was now re‐evaluated (postoperative visit 2) to gain information on long‐term outcomes. Results Out of 121 patients, 92 were eligible for the final analysis at postoperative visit 2. The mean follow‐up interval was 58.5 ± 17.9 months in the NVSSR group and 61.6 ± 10.7 months in the FTDR group. As published previously, presurgical LARS‐like symptoms were observed in 42/92 (45.7%) of patients, including 37/76 (48.7%) in the NVSSR group and 5/16 (31.3%) in the FTDR group. Compared to preoperative LARS scores, patients in the NVSSR group showed a significant reduction of LARS scores at long‐term postoperative visit 2 (p = <0.001), with LARS scores remaining stable over postoperative visit 1 and visit 2 (p = 0.09) at 5 years postoperatively. In women following FTDR, presurgical and long‐term postoperative visit 2 LARS scores remained statistically unchanged (p < 0.73), with worsening of LARS scores between postoperative visit 1 and visit 2 (p = 0.02). In contrast, significant improvement of GIQLI was observed between the preoperative visit and postoperative visit 2 at 5 years follow‐up in both NVSSR and FTDR groups (p ≤ 0.001 and p = 0.001, respectively). Conclusions Compared to presurgical values, long‐term gastrointestinal function reflected by LARS scores remains improved following NVSSR, whereas it remains unchanged following FTDR. However, when GIQLI is applied as patient‐reported outcome measurement (PROM), patients show permanent, long‐term improvement of gastrointestinal function following either NVSSR or FTDR for symptomatic colorectal endometriosis. |
| format | Article |
| id | doaj-art-c53dbbe9e5a849c5b7e3c15f2288f0e7 |
| institution | Kabale University |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-c53dbbe9e5a849c5b7e3c15f2288f0e72025-08-20T03:31:24ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122025-08-0110481550155710.1111/aogs.15142Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosisDaria Pashkunova0Ezgi Darici Kurt1Theresa Hudelist2Anna Rath3Attila Bokor4Gernot Hudelist5Department of Gynecology, Center for Endometriosis Hospital St. John of God Vienna AustriaDepartment of Obstetrics and Gynecology, Center for Endometriosis Semmelweis University Budapest HungaryParacelsus Medical University Nuernberg GermanyDepartment of Gynecology, Center for Endometriosis Hospital St. John of God Vienna AustriaDepartment of Obstetrics and Gynecology, Center for Endometriosis Semmelweis University Budapest HungaryDepartment of Gynecology, Center for Endometriosis Hospital St. John of God Vienna AustriaAbstract Introduction Patients undergoing colorectal surgery for symptomatic deep endometriosis may experience postoperative impairment of gastrointestinal function. However, there is limited information on long‐term follow‐up of this surgical sequela. We aimed to analyze 5‐year postsurgical outcomes of gastrointestinal function in these patients, reflected by lower anterior resection syndrome (LARS) scores and gastrointestinal quality of life index (GIQLI). Material and Methods This prospective study included patients who either underwent nerve‐vessel‐sparing segmental resection (NVSSR) or full‐thickness discoid resection (FTDR) for symptomatic colorectal deep endometriosis from April 2017 to May 2022 at two tertiary referral centers. As published previously, gastrointestinal function was evaluated by LARS and GIQLI scores pre‐ and postsurgically (postoperative visit 1) and was now re‐evaluated (postoperative visit 2) to gain information on long‐term outcomes. Results Out of 121 patients, 92 were eligible for the final analysis at postoperative visit 2. The mean follow‐up interval was 58.5 ± 17.9 months in the NVSSR group and 61.6 ± 10.7 months in the FTDR group. As published previously, presurgical LARS‐like symptoms were observed in 42/92 (45.7%) of patients, including 37/76 (48.7%) in the NVSSR group and 5/16 (31.3%) in the FTDR group. Compared to preoperative LARS scores, patients in the NVSSR group showed a significant reduction of LARS scores at long‐term postoperative visit 2 (p = <0.001), with LARS scores remaining stable over postoperative visit 1 and visit 2 (p = 0.09) at 5 years postoperatively. In women following FTDR, presurgical and long‐term postoperative visit 2 LARS scores remained statistically unchanged (p < 0.73), with worsening of LARS scores between postoperative visit 1 and visit 2 (p = 0.02). In contrast, significant improvement of GIQLI was observed between the preoperative visit and postoperative visit 2 at 5 years follow‐up in both NVSSR and FTDR groups (p ≤ 0.001 and p = 0.001, respectively). Conclusions Compared to presurgical values, long‐term gastrointestinal function reflected by LARS scores remains improved following NVSSR, whereas it remains unchanged following FTDR. However, when GIQLI is applied as patient‐reported outcome measurement (PROM), patients show permanent, long‐term improvement of gastrointestinal function following either NVSSR or FTDR for symptomatic colorectal endometriosis.https://doi.org/10.1111/aogs.15142deep endometriosisfull‐thickness discoid resectiongastrointestinal quality of life indexlow anterior resection syndromenerve vessel sparing segmental resection |
| spellingShingle | Daria Pashkunova Ezgi Darici Kurt Theresa Hudelist Anna Rath Attila Bokor Gernot Hudelist Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis Acta Obstetricia et Gynecologica Scandinavica deep endometriosis full‐thickness discoid resection gastrointestinal quality of life index low anterior resection syndrome nerve vessel sparing segmental resection |
| title | Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis |
| title_full | Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis |
| title_fullStr | Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis |
| title_full_unstemmed | Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis |
| title_short | Long‐term gastrointestinal function outcomes of women undergoing nerve‐vessel sparing segmental or full‐thickness discoid resection for deep colorectal endometriosis |
| title_sort | long term gastrointestinal function outcomes of women undergoing nerve vessel sparing segmental or full thickness discoid resection for deep colorectal endometriosis |
| topic | deep endometriosis full‐thickness discoid resection gastrointestinal quality of life index low anterior resection syndrome nerve vessel sparing segmental resection |
| url | https://doi.org/10.1111/aogs.15142 |
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